Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 256897..257471 Replicon chromosome
Accession NZ_CP073238
Organism Pasteurella multocida strain HuN001

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag KCI89_RS01195 Protein ID WP_061406134.1
Coordinates 256897..257181 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag KCI89_RS01200 Protein ID WP_061406133.1
Coordinates 257178..257471 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KCI89_RS01175 (KCI89_01175) 252690..254279 - 1590 WP_081106270.1 AAA family ATPase -
KCI89_RS01180 (KCI89_01180) 254564..255055 - 492 WP_256447825.1 NERD domain-containing protein -
KCI89_RS01185 (KCI89_01185) 255283..255618 + 336 WP_223848039.1 DUF3418 domain-containing protein -
KCI89_RS01195 (KCI89_01195) 256897..257181 + 285 WP_061406134.1 hypothetical protein Toxin
KCI89_RS01200 (KCI89_01200) 257178..257471 + 294 WP_061406133.1 putative addiction module antidote protein Antitoxin
KCI89_RS01205 (KCI89_01205) 257874..258551 - 678 WP_005726756.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
KCI89_RS01210 (KCI89_01210) 258569..259036 - 468 WP_064661066.1 PTS sugar transporter subunit IIA -
KCI89_RS01215 (KCI89_01215) 259081..260871 - 1791 WP_061406132.1 PTS ascorbate-specific subunit IIBC -
KCI89_RS01220 (KCI89_01220) 261222..262313 + 1092 WP_005751571.1 L-ascorbate 6-phosphate lactonase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-87)

Antitoxin

Uncharacterized protein HI1420

(7-92)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10667.40 Da        Isoelectric Point: 10.2297

>T199606 WP_061406134.1 NZ_CP073238:256897-257181 [Pasteurella multocida]
VGRLKEVKILSAKSAVLARINKAMNGNFGDHKSIGNGLYEMRIIKGSGYRVYYGQYREVTYLLICGGDKSTQKSDIVKAR
ELWKEIKQQEEVKV

Download         Length: 285 bp

>T199606 NZ_CP097421:228-644 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTAGCCGGGACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10947.88 Da        Isoelectric Point: 8.9149

>AT199606 WP_061406133.1 NZ_CP073238:257178-257471 [Pasteurella multocida]
MSKKKIKLKLFDIAEHLDSEEMIAAYLSEVLETCDTNEFISALSDVVRAKGMTELAAKTGLRRESLYKTLSYGSKPRFDT
IMKIMHSLGIKLVPTHI

Download         Length: 294 bp

>AT199606 NZ_CP097421:1-231 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References