Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 1..79816 Replicon plasmid pkle02
Accession NZ_CP073237
Organism Klebsiella pasteurii strain Sb-24

Toxin (Protein)


Gene name tacT Uniprot ID A0A5E1AVR5
Locus tag KCG39_RS27240 Protein ID WP_013087172.1
Coordinates 1..486 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A5E1AWX8
Locus tag KCG39_RS27235 Protein ID WP_012540086.1
Coordinates 79816..13 (+) Length -26600.666666667 a.a.

Genomic Context


KCG39_RS27240KCG39_RS27845KCG39_RS27245KCG39_RS27250KCG39_RS27255KCG39_RS27260KCG39_RS27850KCG39_RS27265KCG39_RS27270KCG39_RS27275KCG39_RS27280KCG39_RS27285KCG39_RS27290KCG39_RS27295KCG39_RS27300KCG39_RS27305KCG39_RS27310KCG39_RS27315KCG39_RS27320KCG39_RS27325KCG39_RS27330KCG39_RS27335KCG39_RS27340KCG39_RS27345KCG39_RS27350KCG39_RS27385KCG39_RS27860KCG39_RS27415KCG39_RS27420KCG39_RS27485KCG39_RS27500KCG39_RS27520KCG39_RS27530KCG39_RS27535KCG39_RS27865KCG39_RS27565KCG39_RS27870KCG39_RS27570KCG39_RS27575KCG39_RS27580KCG39_RS27585KCG39_RS27590KCG39_RS27875KCG39_RS27595KCG39_RS27600KCG39_RS27605KCG39_RS27610KCG39_RS27615KCG39_RS27620KCG39_RS27625KCG39_RS27630KCG39_RS27635KCG39_RS27640KCG39_RS27645KCG39_RS27650KCG39_RS27355KCG39_RS27360KCG39_RS27365KCG39_RS27370KCG39_RS27375KCG39_RS27380KCG39_RS27395KCG39_RS27400KCG39_RS27405KCG39_RS27410KCG39_RS27425KCG39_RS27430KCG39_RS27435KCG39_RS27440KCG39_RS27445KCG39_RS27450KCG39_RS27455KCG39_RS27460KCG39_RS27465KCG39_RS27470KCG39_RS27475KCG39_RS27480KCG39_RS27490KCG39_RS27495KCG39_RS27505KCG39_RS27510KCG39_RS27525KCG39_RS27540KCG39_RS27545KCG39_RS27550KCG39_RS27555KCG39_RS27560KCG39_RS27655KCG39_RS27660KCG39_RS27665KCG39_RS27670KCG39_RS27675KCG39_RS27680
Location: 1..486 (486 bp)
Type: Toxin
Protein ID: WP_013087172.1
Location: 769..921 (153 bp)
Type: Others
Protein ID: Protein_2
Location: 866..988 (123 bp)
Type: Others
Protein ID: WP_085842394.1
Location: 1366..1635 (270 bp)
Type: Others
Protein ID: WP_038807148.1
Location: 1632..1982 (351 bp)
Type: Others
Protein ID: WP_063106385.1
Location: 1997..2314 (318 bp)
Type: Others
Protein ID: WP_038807150.1
Location: 2953..3198 (246 bp)
Type: Others
Protein ID: WP_074155869.1
Location: 3185..3403 (219 bp)
Type: Others
Protein ID: Protein_8
Location: 3406..3828 (423 bp)
Type: Others
Protein ID: Protein_9
Location: 3984..4577 (594 bp)
Type: Others
Protein ID: WP_049141667.1
Location: 5254..5898 (645 bp)
Type: Others
Protein ID: WP_211811642.1
Location: 5954..6604 (651 bp)
Type: Others
Protein ID: WP_211811643.1
Location: 6601..6909 (309 bp)
Type: Others
Protein ID: WP_211811644.1
Location: 7009..7560 (552 bp)
Type: Others
Protein ID: WP_266098453.1
Location: 7693..7953 (261 bp)
Type: Others
Protein ID: WP_075211167.1
Location: 8179..8256 (78 bp)
Type: Others
Protein ID: WP_071846032.1
Location: 8249..9274 (1026 bp)
Type: Others
Protein ID: WP_211811645.1
Location: 10337..11488 (1152 bp)
Type: Others
Protein ID: WP_075912867.1
Location: 11492..13627 (2136 bp)
Type: Others
Protein ID: WP_211811646.1
Location: 13624..13890 (267 bp)
Type: Others
Protein ID: WP_211811647.1
Location: 14270..14761 (492 bp)
Type: Others
Protein ID: Protein_21
Location: 14997..16217 (1221 bp)
Type: Others
Protein ID: WP_211811648.1
Location: 16514..17065 (552 bp)
Type: Others
Protein ID: WP_211811649.1
Location: 17363..17827 (465 bp)
Type: Others
Protein ID: WP_211811650.1
Location: 17799..18218 (420 bp)
Type: Others
Protein ID: WP_211811651.1
Location: 21046..21363 (318 bp)
Type: Others
Protein ID: Protein_32
Location: 25250..25339 (90 bp)
Type: Others
Protein ID: Protein_37
Location: 26041..26523 (483 bp)
Type: Others
Protein ID: Protein_39
Location: 26968..28078 (1111 bp)
Type: Others
Protein ID: Protein_40
Location: 40812..41780 (969 bp)
Type: Others
Protein ID: WP_211811630.1
Location: 43960..44523 (564 bp)
Type: Others
Protein ID: WP_211811633.1
Location: 47936..48676 (741 bp)
Type: Others
Protein ID: WP_001515717.1
Location: 51211..52377 (1167 bp)
Type: Others
Protein ID: WP_000523815.1
Location: 52377..53342 (966 bp)
Type: Others
Protein ID: WP_032740676.1
Location: 58264..58494 (231 bp)
Type: Others
Protein ID: WP_032740680.1
Location: 59592..61163 (1572 bp)
Type: Others
Protein ID: WP_049010905.1
Location: 61179..61343 (165 bp)
Type: Others
Protein ID: Protein_71
Location: 61792..62220 (429 bp)
Type: Others
Protein ID: WP_211811638.1
Location: 62265..62771 (507 bp)
Type: Others
Protein ID: WP_046622857.1
Location: 62814..63005 (192 bp)
Type: Others
Protein ID: WP_049010907.1
Location: 63206..63460 (255 bp)
Type: Others
Protein ID: WP_165454128.1
Location: 63495..63815 (321 bp)
Type: Others
Protein ID: WP_049010910.1
Location: 64266..64469 (204 bp)
Type: Others
Protein ID: WP_071592596.1
Location: 64500..65042 (543 bp)
Type: Others
Protein ID: WP_064402442.1
Location: 65091..65339 (249 bp)
Type: Others
Protein ID: WP_211811639.1
Location: 65408..67408 (2001 bp)
Type: Others
Protein ID: WP_211811640.1
Location: 67453..67884 (432 bp)
Type: Others
Protein ID: WP_130940021.1
Location: 67881..68609 (729 bp)
Type: Others
Protein ID: WP_040107916.1
Location: 68606..68932 (327 bp)
Type: Others
Protein ID: WP_038992719.1
Location: 69121..70490 (1370 bp)
Type: Others
Protein ID: WP_211811641.1
Location: 70708..71058 (351 bp)
Type: Others
Protein ID: WP_012540252.1
Location: 71106..71468 (363 bp)
Type: Others
Protein ID: WP_012540111.1
Location: 71486..73237 (1752 bp)
Type: Others
Protein ID: WP_012540169.1
Location: 73285..74574 (1290 bp)
Type: Others
Protein ID: WP_012540054.1
Location: 74587..75012 (426 bp)
Type: Others
Protein ID: WP_012540118.1
Location: 18280..18525 (246 bp)
Type: Others
Protein ID: WP_211811652.1
Location: 18537..18782 (246 bp)
Type: Others
Protein ID: WP_211811653.1
Location: 18803..18997 (195 bp)
Type: Others
Protein ID: WP_211811654.1
Location: 19077..19787 (711 bp)
Type: Others
Protein ID: WP_211811655.1
Location: 19887..20361 (475 bp)
Type: Others
Protein ID: Protein_30
Location: 20476..20823 (348 bp)
Type: Others
Protein ID: WP_142884384.1
Location: 23023..23886 (864 bp)
Type: Others
Protein ID: WP_211811656.1
Location: 23970..24497 (528 bp)
Type: Others
Protein ID: WP_211811657.1
Location: 24505..24774 (270 bp)
Type: Others
Protein ID: WP_048264996.1
Location: 25349..25777 (429 bp)
Type: Others
Protein ID: Protein_38
Location: 28268..29284 (1017 bp)
Type: Others
Protein ID: WP_211811658.1
Location: 29911..30444 (534 bp)
Type: Others
Protein ID: WP_211811659.1
Location: 30461..30979 (519 bp)
Type: Others
Protein ID: WP_211811660.1
Location: 30976..31494 (519 bp)
Type: Others
Protein ID: WP_228299446.1
Location: 31503..32099 (597 bp)
Type: Others
Protein ID: WP_228299447.1
Location: 32147..32875 (729 bp)
Type: Others
Protein ID: WP_211811666.1
Location: 33031..35547 (2517 bp)
Type: Others
Protein ID: WP_211811667.1
Location: 35902..36066 (165 bp)
Type: Others
Protein ID: WP_211811662.1
Location: 36222..36755 (534 bp)
Type: Others
Protein ID: WP_211811663.1
Location: 37218..37676 (459 bp)
Type: Others
Protein ID: Protein_50
Location: 37757..39265 (1509 bp)
Type: Others
Protein ID: WP_211811668.1
Location: 39938..40623 (686 bp)
Type: Others
Protein ID: Protein_52
Location: 42045..42329 (285 bp)
Type: Others
Protein ID: WP_211811631.1
Location: 42507..43070 (564 bp)
Type: Others
Protein ID: WP_211811632.1
Location: 44598..45092 (495 bp)
Type: Others
Protein ID: WP_211811634.1
Location: 45076..45858 (783 bp)
Type: Others
Protein ID: WP_211811635.1
Location: 49459..50469 (1011 bp)
Type: Others
Protein ID: WP_032740675.1
Location: 54698..55072 (375 bp)
Type: Others
Protein ID: WP_074446765.1
Location: 55169..56458 (1290 bp)
Type: Others
Protein ID: WP_032740678.1
Location: 56475..56900 (426 bp)
Type: Others
Protein ID: WP_032740679.1
Location: 56903..57805 (903 bp)
Type: Others
Protein ID: WP_040107984.1
Location: 58885..59181 (297 bp)
Type: Others
Protein ID: WP_211811637.1
Location: 75047..75583 (537 bp)
Type: Others
Protein ID: WP_012540238.1
Location: 75708..77465 (1758 bp)
Type: Others
Protein ID: WP_049010932.1
Location: 77486..77848 (363 bp)
Type: Others
Protein ID: WP_012540155.1
Location: 77924..78469 (546 bp)
Type: Others
Protein ID: WP_012540227.1
Location: 78478..79191 (714 bp)
Type: Others
Protein ID: WP_012540184.1
Location: 79193..79516 (324 bp)
Type: Others
Protein ID: WP_012540250.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KCG39_RS27240 (KCG39_27240)1..486+486WP_013087172.1GNAT family N-acetyltransferaseToxin
KCG39_RS27845769..921+153Protein_2DUF5431 family protein-
KCG39_RS27245 (KCG39_27245)866..988+123WP_085842394.1Hok/Gef family protein-
KCG39_RS27250 (KCG39_27250)1366..1635+270WP_038807148.1hypothetical protein-
KCG39_RS27255 (KCG39_27255)1632..1982+351WP_063106385.1hypothetical protein-
KCG39_RS27260 (KCG39_27260)1997..2314+318WP_038807150.1hypothetical protein-
KCG39_RS278502953..3198+246WP_074155869.1hypothetical protein-
KCG39_RS27265 (KCG39_27265)3185..3403+219Protein_8hypothetical protein-
KCG39_RS27270 (KCG39_27270)3406..3828+423Protein_9TraX family protein-
KCG39_RS27275 (KCG39_27275)3984..4577+594WP_049141667.1fertility inhibition protein FinO-
KCG39_RS27280 (KCG39_27280)5254..5898+645WP_211811642.1hypothetical protein-
KCG39_RS27285 (KCG39_27285)5954..6604+651WP_211811643.1DUF2726 domain-containing protein-
KCG39_RS27290 (KCG39_27290)6601..6909+309WP_211811644.1hypothetical protein-
KCG39_RS27295 (KCG39_27295)7009..7560+552WP_266098453.1phospholipase D family protein-
KCG39_RS27300 (KCG39_27300)7693..7953+261WP_075211167.1replication regulatory protein RepA-
KCG39_RS27305 (KCG39_27305)8179..8256+78WP_071846032.1RepA leader peptide Tap-
KCG39_RS27310 (KCG39_27310)8249..9274+1026WP_211811645.1plasmid replication initiator RepA-
KCG39_RS27315 (KCG39_27315)10337..11488+1152WP_075912867.1tail fiber domain-containing protein-
KCG39_RS27320 (KCG39_27320)11492..13627+2136WP_211811646.1S-type pyocin domain-containing protein-
KCG39_RS27325 (KCG39_27325)13624..13890+267WP_211811647.1colicin immunity domain-containing protein-
KCG39_RS27330 (KCG39_27330)14270..14761+492Protein_21Tn3 family transposase-
KCG39_RS27335 (KCG39_27335)14997..16217+1221WP_211811648.1ISL3 family transposase-
KCG39_RS27340 (KCG39_27340)16514..17065+552WP_211811649.1hypothetical protein-
KCG39_RS27345 (KCG39_27345)17363..17827+465WP_211811650.1hypothetical protein-
KCG39_RS27350 (KCG39_27350)17799..18218+420WP_211811651.1hypothetical protein-
KCG39_RS27355 (KCG39_27355)18280..18525-246WP_211811652.1GrxA family glutaredoxin-
KCG39_RS27360 (KCG39_27360)18537..18782-246WP_211811653.1hypothetical protein-
KCG39_RS27365 (KCG39_27365)18803..18997-195WP_211811654.1hypothetical protein-
KCG39_RS27370 (KCG39_27370)19077..19787-711WP_211811655.1hypothetical protein-
KCG39_RS27375 (KCG39_27375)19887..20361-475Protein_30transposase-
KCG39_RS27380 (KCG39_27380)20476..20823-348WP_142884384.1hypothetical protein-
KCG39_RS27385 (KCG39_27385)21046..21363+318Protein_32AraC family transcriptional regulator-
KCG39_RS27395 (KCG39_27395)23023..23886-864WP_211811656.1hypothetical protein-
KCG39_RS27400 (KCG39_27400)23970..24497-528WP_211811657.1GNAT family N-acetyltransferase-
KCG39_RS27405 (KCG39_27405)24505..24774-270WP_048264996.1DUF1778 domain-containing protein-
KCG39_RS2786025250..25339+90Protein_37transposase-
KCG39_RS27410 (KCG39_27410)25349..25777-429Protein_38transposase-
KCG39_RS27415 (KCG39_27415)26041..26523+483Protein_39integrase core domain-containing protein-
KCG39_RS27420 (KCG39_27420)26968..28078+1111Protein_40IS3 family transposase-
KCG39_RS27425 (KCG39_27425)28268..29284-1017WP_211811658.1hypothetical protein-
KCG39_RS27430 (KCG39_27430)29911..30444-534WP_211811659.1fimbrial protein-
KCG39_RS27435 (KCG39_27435)30461..30979-519WP_211811660.1fimbrial protein-
KCG39_RS27440 (KCG39_27440)30976..31494-519WP_228299446.1fimbrial protein-
KCG39_RS27445 (KCG39_27445)31503..32099-597WP_228299447.1fimbrial protein-
KCG39_RS27450 (KCG39_27450)32147..32875-729WP_211811666.1fimbria/pilus periplasmic chaperone-
KCG39_RS27455 (KCG39_27455)33031..35547-2517WP_211811667.1outer membrane usher protein-
KCG39_RS27460 (KCG39_27460)35902..36066-165WP_211811662.1hypothetical protein-
KCG39_RS27465 (KCG39_27465)36222..36755-534WP_211811663.1fimbrial protein-
KCG39_RS27470 (KCG39_27470)37218..37676-459Protein_50IS3 family transposase-
KCG39_RS27475 (KCG39_27475)37757..39265-1509WP_211811668.1group II intron reverse transcriptase/maturase-
KCG39_RS27480 (KCG39_27480)39938..40623-686Protein_52IS3 family transposase-
KCG39_RS27485 (KCG39_27485)40812..41780+969WP_211811630.1IS110 family transposase-
KCG39_RS27490 (KCG39_27490)42045..42329-285WP_211811631.1hypothetical protein-
KCG39_RS27495 (KCG39_27495)42507..43070-564WP_211811632.1helix-turn-helix transcriptional regulator-
KCG39_RS27500 (KCG39_27500)43960..44523+564WP_211811633.1helix-turn-helix transcriptional regulator-
KCG39_RS27505 (KCG39_27505)44598..45092-495WP_211811634.1hypothetical protein-
KCG39_RS27510 (KCG39_27510)45076..45858-783WP_211811635.1helix-turn-helix domain-containing protein-
KCG39_RS27520 (KCG39_27520)47936..48676+741WP_001515717.1tyrosine-type recombinase/integrase-
KCG39_RS27525 (KCG39_27525)49459..50469-1011WP_032740675.1RepB family plasmid replication initiator protein-
KCG39_RS27530 (KCG39_27530)51211..52377+1167WP_000523815.1plasmid-partitioning protein SopA-
KCG39_RS27535 (KCG39_27535)52377..53342+966WP_032740676.1ParB/RepB/Spo0J family plasmid partition protein-
KCG39_RS27540 (KCG39_27540)54698..55072-375WP_074446765.1fluoride efflux transporter CrcB-
KCG39_RS27545 (KCG39_27545)55169..56458-1290WP_032740678.1phosphopyruvate hydratase-
KCG39_RS27550 (KCG39_27550)56475..56900-426WP_032740679.1universal stress protein-
KCG39_RS27555 (KCG39_27555)56903..57805-903WP_040107984.1DHH family phosphoesterase-
KCG39_RS2786558264..58494+231WP_032740680.1hypothetical protein-
KCG39_RS27560 (KCG39_27560)58885..59181-297WP_211811637.1hypothetical protein-
KCG39_RS27565 (KCG39_27565)59592..61163+1572WP_049010905.1sensor domain-containing diguanylate cyclase-
KCG39_RS2787061179..61343+165Protein_71hypothetical protein-
KCG39_RS27570 (KCG39_27570)61792..62220+429WP_211811638.1antirestriction protein-
KCG39_RS27575 (KCG39_27575)62265..62771+507WP_046622857.1antirestriction protein ArdA-
KCG39_RS27580 (KCG39_27580)62814..63005+192WP_049010907.1hypothetical protein-
KCG39_RS27585 (KCG39_27585)63206..63460+255WP_165454128.1DNA polymerase III subunit theta-
KCG39_RS27590 (KCG39_27590)63495..63815+321WP_049010910.1hypothetical protein-
KCG39_RS2787564266..64469+204WP_071592596.1hypothetical protein-
KCG39_RS27595 (KCG39_27595)64500..65042+543WP_064402442.1single-stranded DNA-binding protein-
KCG39_RS27600 (KCG39_27600)65091..65339+249WP_211811639.1DUF905 domain-containing protein-
KCG39_RS27605 (KCG39_27605)65408..67408+2001WP_211811640.1ParB/RepB/Spo0J family partition protein-
KCG39_RS27610 (KCG39_27610)67453..67884+432WP_130940021.1conjugation system SOS inhibitor PsiB-
KCG39_RS27615 (KCG39_27615)67881..68609+729WP_040107916.1plasmid SOS inhibition protein A-
KCG39_RS27620 (KCG39_27620)68606..68932+327WP_038992719.1hypothetical protein-
KCG39_RS27625 (KCG39_27625)69121..70490+1370WP_211811641.1IS3 family transposase-
KCG39_RS27630 (KCG39_27630)70708..71058+351WP_012540252.1As(III)-sensing metalloregulatory transcriptional repressor ArsR-
KCG39_RS27635 (KCG39_27635)71106..71468+363WP_012540111.1arsenite efflux transporter metallochaperone ArsD-
KCG39_RS27640 (KCG39_27640)71486..73237+1752WP_012540169.1arsenite efflux transporter ATPase subunit ArsA-
KCG39_RS27645 (KCG39_27645)73285..74574+1290WP_012540054.1arsenite efflux transporter membrane subunit ArsB-
KCG39_RS27650 (KCG39_27650)74587..75012+426WP_012540118.1glutaredoxin-dependent arsenate reductase-
KCG39_RS27655 (KCG39_27655)75047..75583-537WP_012540238.1GNAT family N-acetyltransferase-
KCG39_RS27660 (KCG39_27660)75708..77465-1758WP_049010932.1arsenical pump-driving ATPase-
KCG39_RS27665 (KCG39_27665)77486..77848-363WP_012540155.1arsenic metallochaperone ArsD family protein-
KCG39_RS27670 (KCG39_27670)77924..78469-546WP_012540227.1sigma-70 family RNA polymerase sigma factor-
KCG39_RS27675 (KCG39_27675)78478..79191-714WP_012540184.1arsenical resistance protein ArsH-
KCG39_RS27680 (KCG39_27680)79193..79516-324WP_012540250.1metalloregulator ArsR/SmtB family transcription factor-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..8006980069
-insideIScluster/Tn--21432..278846452


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(27-152)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 162 a.a.        Molecular weight: 17810.62 Da        Isoelectric Point: 9.8560

>T199604 WP_013087172.1 NZ_CP073237:1-486 [Klebsiella pasteurii]
VGRVTVPEPLSSFHQVAEFVCGETVLDDWLKQKGLKNQALGSARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQQRTLFLKLP
Q

Download         Length: 486 bp

>T199604 NZ_CP097419:c5256135-5256033 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: -26600.666666667 a.a.        Molecular weight: Da        Isoelectric Point:

>AT199604 WP_012540086.1 NZ_CP073237:79816-13 [Klebsiella pasteurii]

Download         Length: -79802 bp

>AT199604 NZ_CP097419:5256027-5256171 [Klebsiella pneumoniae]
ACATATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGT
TGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A5E1AVR5


Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A5E1AWX8

References