Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4409506..4410183 Replicon chromosome
Accession NZ_CP073236
Organism Klebsiella pasteurii strain Sb-24

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag KCG39_RS20710 Protein ID WP_211811454.1
Coordinates 4409506..4409832 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag KCG39_RS20715 Protein ID WP_211811455.1
Coordinates 4409857..4410183 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KCG39_RS20700 (KCG39_20700) 4406848..4407765 + 918 WP_211811452.1 hypothetical protein -
KCG39_RS20705 (KCG39_20705) 4407767..4408810 - 1044 WP_211811453.1 DNA methyltransferase -
KCG39_RS20710 (KCG39_20710) 4409506..4409832 - 327 WP_211811454.1 TA system toxin CbtA family protein Toxin
KCG39_RS20715 (KCG39_20715) 4409857..4410183 - 327 WP_211811455.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KCG39_RS20720 (KCG39_20720) 4410226..4410627 - 402 WP_228299440.1 DNA repair protein RadC -
KCG39_RS20725 (KCG39_20725) 4410718..4411170 - 453 WP_228299441.1 antirestriction protein -
KCG39_RS20730 (KCG39_20730) 4411243..4412061 - 819 WP_211811457.1 DUF932 domain-containing protein -
KCG39_RS20735 (KCG39_20735) 4412526..4413149 + 624 WP_211811458.1 inovirus Gp2 family protein -
KCG39_RS20740 (KCG39_20740) 4413268..4413483 + 216 WP_211811459.1 AlpA family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4402490..4421171 18681


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(7-107)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12444.33 Da        Isoelectric Point: 8.5103

>T199601 WP_211811454.1 NZ_CP073236:c4409832-4409506 [Klebsiella pasteurii]
MKILSENQRGAKPCPPPVLVWQTLLTRLLEQHYGLTLNDTPFSDETVIQEHIDAGITLADAVNFLVEKYELVRIDRRGFN
CQEQSPYLRAVDILRARQATGLLKRNRR

Download         Length: 327 bp

>T199601 NZ_CP097419:2495562-2496095 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12514.01 Da        Isoelectric Point: 5.4492

>AT199601 WP_211811455.1 NZ_CP073236:c4410183-4409857 [Klebsiella pasteurii]
MEKHDNPEWGLRCDVMPRFSARLVQEGNRLHYLADRAGITGAFEEEECHQLNSAFPHFTEQMELMLLSGELNPRHAHRVT
LYHDELTCEADTLGSHGYVYIAIYPTQR

Download         Length: 327 bp

>AT199601 NZ_CP097419:2495285-2495551 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References