Detailed information of TA system TA199589

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): EcnAB/-
• Location: 4691548..4691909
• Replicon: chromosome
• Accession: NZ_CP073209
• Organism: Xanthomonas citri pv. mangiferaeindicae strain GXG07

Toxin (Protein)

• Gene name: EcnB
• Uniprot ID: -
• Locus tag: XCM_RS20360
• Protein ID: WP_033482596.1
• Coordinates: 4691548..4691682 (-)
• Length: 45 a.a.

Antitoxin (Protein)

• Gene name: EcnA
• Uniprot ID: H8FG64
• Locus tag: XCM_RS20365
• Protein ID: WP_003486606.1
• Coordinates: 4691757..4691909 (-)
• Length: 51 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XCM_RS20340 (XCM_20180)	4686685..4688376	-	1692	WP_033482594.1	M28 family metallopeptidase	-
XCM_RS20345 (XCM_20185)	4688568..4689512	-	945	WP_003486596.1	MBL fold metallo-hydrolase	-
XCM_RS20350 (XCM_20190)	4689641..4690930	-	1290	WP_003486598.1	tryptophan--tRNA ligase	-
XCM_RS20355 (XCM_20195)	4691112..4691321	-	210	WP_003486601.1	CsbD family protein	-
XCM_RS20360 (XCM_20200)	4691548..4691682	-	135	WP_033482596.1	entericidin A/B family lipoprotein	Toxin
XCM_RS20365 (XCM_20205)	4691757..4691909	-	153	WP_003486606.1	entericidin A/B family lipoprotein	Antitoxin
XCM_RS20370 (XCM_20210)	4692016..4692939	-	924	WP_003486608.1	arginase	-
XCM_RS20375 (XCM_20215)	4693260..4693712	+	453	WP_003486611.1	roadblock/LC7 domain-containing protein	-
XCM_RS20380 (XCM_20220)	4693776..4694135	+	360	WP_003486613.1	hypothetical protein	-
XCM_RS20385 (XCM_20225)	4694232..4695149	+	918	WP_033482597.1	hypothetical protein	-
XCM_RS20390 (XCM_20230)	4695146..4695688	+	543	WP_003486615.1	GTPase	-
XCM_RS20395 (XCM_20235)	4696126..4696809	+	684	WP_003486617.1	dTMP kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Entericidin A/B (23-42)

Antitoxin

• Entericidin A/B (23-42)

Sequences

Toxin

Protein

• Length: 45 a.a.
• Molecular weight: 4503.38 Da
• Isoelectric Point: 9.3487

>T199589 WP_033482596.1 NZ_CP073209:c4691682-4691548 [Xanthomonas citri pv. mangiferaeindicae]
MKRTIVLLVLSMLSVAMLAGCNTVAGAGKDVQGAGEKVEDAARK

Nucleotide

• Length: 135 bp

>T199589 NZ_CP097415:c4712710-4712369 [Klebsiella pneumoniae]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGTGACGCTATGTCTGTCGTCTGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAAGGGATTC
AACTGGCAAGAACACTCCCCATATCTGCGGGCAGTTGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGCGCCGAAG
CCGTAAAAATGCTGTACGTTAA

Antitoxin

Protein

• Length: 51 a.a.
• Molecular weight: 5122.07 Da
• Isoelectric Point: 8.7942

>AT199589 WP_003486606.1 NZ_CP073209:c4691909-4691757 [Xanthomonas citri pv. mangiferaeindicae]
MKRLLTLMVLGLFSAGVMTGCNTVAGAGKDMQGAGNKVEKTAEKCSDGKC

Nucleotide

• Length: 153 bp

>AT199589 NZ_CP097415:c4713072-4712731 [Klebsiella pneumoniae]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTCAAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGACTTCACTATCTGGCTGACCGGGCCAGCATTACCGGTGAATTCAGCAACGCAGAATCTT
TGAAGTTGGATGAGGTATTCCCACATTTTATCAGCCAGATGGAGTCGATGCTGACTACTGGTGAAATGAATCCTCGCCAT
GCCCACTTTTTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTACGGCTACGTATACATCGC
CGTTTACCCCACTCAACGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A828YLX6