Detailed information of TA system TA199588

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 100442..100986
• Replicon: chromosome
• Accession: NZ_CP073209
• Organism: Xanthomonas citri pv. mangiferaeindicae strain GXG07

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: XCM_RS00445
• Protein ID: WP_015462700.1
• Coordinates: 100708..100986 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: H8FI25
• Locus tag: XCM_RS00440
• Protein ID: WP_003487884.1
• Coordinates: 100442..100699 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XCM_RS00420 (XCM_0415)	95497..96459	-	963	WP_011347617.1	IS1595-like element IS1595 family transposase	-
XCM_RS00425	96530..97042	-	513	Protein_82	exonuclease	-
XCM_RS00430 (XCM_0420)	97039..99534	-	2496	WP_003487880.1	DEAD/DEAH box helicase	-
XCM_RS00435 (XCM_0425)	99712..100374	+	663	WP_005912558.1	hemolysin III family protein	-
XCM_RS00440 (XCM_0430)	100442..100699	+	258	WP_003487884.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
XCM_RS00445 (XCM_0435)	100708..100986	+	279	WP_015462700.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
XCM_RS00455 (XCM_0440)	101166..102065	-	900	WP_003487887.1	SDR family NAD(P)-dependent oxidoreductase	-
XCM_RS00460 (XCM_0445)	102124..102861	-	738	WP_003487890.1	SDR family oxidoreductase	-
XCM_RS00465 (XCM_0450)	102987..103898	+	912	WP_003487892.1	LysR family transcriptional regulator	-
XCM_RS00470 (XCM_0455)	104096..104806	+	711	WP_003487894.1	hypothetical protein	-
XCM_RS00475 (XCM_0460)	105063..105671	-	609	WP_003487896.1	NAD(P)H-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	95497..96459	962

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10400.97 Da
• Isoelectric Point: 10.1557

>T199588 WP_015462700.1 NZ_CP073209:100708-100986 [Xanthomonas citri pv. mangiferaeindicae]
VPALADLDAIADYIAIDNAPAAAALVKRVFGHVEQLIEHPDSGSRPQELKRSRYRQIVEPPCRVFYRVDGQRIVVVHVMR
SERALRGNRLSR

Nucleotide

• Length: 279 bp

>T199588 NZ_CP097415:c4682238-4681705 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9683.21 Da
• Isoelectric Point: 9.8274

>AT199588 WP_003487884.1 NZ_CP073209:100442-100699 [Xanthomonas citri pv. mangiferaeindicae]
MRTELVTTLKRQATELLAAAERDKEPILITQHGLPSAYLVDVASYERMQQRIALLEGIARGEMAVAEGRTLSHEQARHRM
ARWLK

Nucleotide

• Length: 258 bp

>AT199588 NZ_CP097415:c4682515-4682249 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Antitoxin

• AlphaFold DB: H8FI25