Detailed information of TA system TA199587

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 2156717..2157391
• Replicon: chromosome
• Accession: NZ_CP073118
• Organism: Neisseria subflava strain CG0073

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: KCG53_RS11020
• Protein ID: WP_049343624.1
• Coordinates: 2156717..2156899 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: KCG53_RS11025
• Protein ID: WP_254346596.1
• Coordinates: 2156975..2157391 (+)
• Length: 139 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KCG53_RS11000 (KCG53_10530)	2152432..2153154	-	723	WP_254346593.1	tRNA adenosine(34) deaminase TadA	-
KCG53_RS11005 (KCG53_10535)	2153158..2154099	-	942	WP_254346594.1	tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA	-
KCG53_RS11010 (KCG53_10540)	2154317..2155369	+	1053	WP_004519884.1	biotin synthase BioB	-
KCG53_RS11015 (KCG53_10545)	2155416..2156426	-	1011	WP_254346595.1	adenosine deaminase	-
KCG53_RS11020 (KCG53_10550)	2156717..2156899	+	183	WP_049343624.1	type II toxin-antitoxin system HicA family toxin	Toxin
KCG53_RS11025 (KCG53_10555)	2156975..2157391	+	417	WP_254346596.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
KCG53_RS11030 (KCG53_10560)	2157451..2157963	-	513	WP_254346598.1	hypothetical protein	-
KCG53_RS11035 (KCG53_10565)	2157960..2158436	-	477	WP_254346599.1	D-Ala-D-Ala carboxypeptidase family metallohydrolase	-
KCG53_RS11040 (KCG53_10570)	2158487..2158903	-	417	WP_254346601.1	hypothetical protein	-
KCG53_RS11045	2158948..2159211	-	264	WP_254346608.1	hypothetical protein	-
KCG53_RS11050 (KCG53_10580)	2159335..2159787	-	453	WP_254346614.1	hypothetical protein	-
KCG53_RS11055	2159789..2160373	-	585	WP_254346616.1	hypothetical protein	-
KCG53_RS11060 (KCG53_10590)	2160382..2160768	-	387	WP_254346618.1	hypothetical protein	-
KCG53_RS11065 (KCG53_10595)	2160765..2161217	-	453	WP_254346620.1	phosphodiester glycosidase family protein	-
KCG53_RS11070	2161208..2161903	-	696	WP_254346622.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2155416..2193452	38036

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-58)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6860.04 Da
• Isoelectric Point: 10.8207

>T199587 WP_049343624.1 NZ_CP073118:2156717-2156899 [Neisseria subflava]
MKYSEFRKWLLSQGVEFTTLKRGSHQLIKLGNKTSVFPNHGSKEIGTGLVQKIKKDLDLK

Nucleotide

• Length: 183 bp

>T199587 NZ_CP097415:4040406-4040624 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 139 a.a.
• Molecular weight: 15400.74 Da
• Isoelectric Point: 4.4082

>AT199587 WP_254346596.1 NZ_CP073118:2156975-2157391 [Neisseria subflava]
MLAYPYILTPDDNGTLLVTFPDIPEAVAVGEDEDTAKIEAIDGLICALEGYFEDRKAVPMPSENDGEHVVVLPALETAKI
LLLNEMVQQNVKKAEMARRLDVHMPQIDRLLNLRHNTKLDFLEKAAEKLGKNLNISFS

Nucleotide

• Length: 417 bp

>AT199587 NZ_CP097415:4040005-4040379 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG