Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-YefM
Location 497991..498499 Replicon chromosome
Accession NZ_CP073116
Organism Neisseria subflava strain TT0073

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag KCG56_RS02375 Protein ID WP_254321788.1
Coordinates 497991..498254 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KCG56_RS02380 Protein ID WP_223169026.1
Coordinates 498251..498499 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KCG56_RS02355 (KCG56_02370) 493382..494896 + 1515 WP_254321784.1 hypothetical protein -
KCG56_RS02360 (KCG56_02375) 494918..496390 + 1473 WP_254321785.1 DUF935 family protein -
KCG56_RS02365 (KCG56_02380) 496390..497295 + 906 WP_254321786.1 phage minor head protein -
KCG56_RS02370 (KCG56_02385) 497298..497738 + 441 WP_254321787.1 phage virion morphogenesis protein -
KCG56_RS02375 (KCG56_02390) 497991..498254 - 264 WP_254321788.1 Txe/YoeB family addiction module toxin Toxin
KCG56_RS02380 (KCG56_02395) 498251..498499 - 249 WP_223169026.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
KCG56_RS02385 (KCG56_02400) 498855..499022 + 168 WP_164836862.1 hypothetical protein -
KCG56_RS02390 (KCG56_02405) 499134..499532 + 399 WP_254321789.1 TrbM/KikA/MpfK family conjugal transfer protein -
KCG56_RS02395 499474..499686 + 213 WP_254321790.1 TrbM/KikA/MpfK family conjugal transfer protein -
KCG56_RS02400 (KCG56_02410) 499837..500616 + 780 WP_254321791.1 conjugal transfer protein TraL -
KCG56_RS02405 (KCG56_02415) 500598..501032 + 435 WP_254321792.1 hypothetical protein -
KCG56_RS02410 (KCG56_02420) 501301..501627 + 327 WP_254321793.1 helix-turn-helix domain-containing protein -
KCG56_RS02415 (KCG56_02425) 501549..502523 + 975 WP_254322205.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 413356..502679 89323


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(4-75)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10578.03 Da        Isoelectric Point: 9.9154

>T199586 WP_254321788.1 NZ_CP073116:c498254-497991 [Neisseria subflava]
VRKHRFTADAAEDLAYWKKHDARKVERIKLLLEDIKANHPKEIGKPEPLRHHKSSLWSRRIDREHRLVYSVDEDTVTVYA
CRYHYER

Download         Length: 264 bp

>T199586 NZ_CP097415:c2645913-2644591 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTACTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCGGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCTACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9233.33 Da        Isoelectric Point: 4.0737

>AT199586 WP_223169026.1 NZ_CP073116:c498499-498251 [Neisseria subflava]
MDYVISYTAAREDLAQVMTKVCEDQVVTHITRRNGGNCVLMSEEEYSSIMETLYLFGNPTNAARLEHSLAQAEQGEFVEV
DL

Download         Length: 249 bp

>AT199586 NZ_CP097415:c2646179-2645913 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References