Detailed information of TA system TA199585

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-YefM
• Location: 2199479..2199987
• Replicon: chromosome
• Accession: NZ_CP073115
• Organism: Neisseria subflava strain TT0077

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: KCG54_RS10630
• Protein ID: WP_079453728.1
• Coordinates: 2199724..2199987 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KCG54_RS10625
• Protein ID: WP_223169026.1
• Coordinates: 2199479..2199727 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KCG54_RS10590 (KCG54_10610)	2195074..2195241	-	168	WP_168162757.1	hypothetical protein	-
KCG54_RS10595 (KCG54_10615)	2195322..2195708	-	387	WP_254324144.1	hypothetical protein	-
KCG54_RS10600 (KCG54_10620)	2195714..2196010	-	297	WP_254324145.1	hypothetical protein	-
KCG54_RS10605 (KCG54_10625)	2196605..2197198	-	594	WP_254324146.1	hypothetical protein	-
KCG54_RS10610 (KCG54_10630)	2197244..2197876	-	633	WP_254324147.1	LexA family transcriptional regulator	-
KCG54_RS10615 (KCG54_10635)	2197989..2198204	+	216	WP_049351607.1	helix-turn-helix transcriptional regulator	-
KCG54_RS10620 (KCG54_10640)	2198207..2198968	+	762	WP_254324148.1	hypothetical protein	-
KCG54_RS10625 (KCG54_10645)	2199479..2199727	+	249	WP_223169026.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
KCG54_RS10630 (KCG54_10650)	2199724..2199987	+	264	WP_079453728.1	Txe/YoeB family addiction module toxin	Toxin
KCG54_RS10635 (KCG54_10655)	2200034..2200417	-	384	WP_254324149.1	hypothetical protein	-
KCG54_RS10640 (KCG54_10660)	2201065..2201463	+	399	WP_254324150.1	phosphoglycerate kinase	-
KCG54_RS10645 (KCG54_10665)	2201517..2202305	+	789	WP_254324151.1	N-6 DNA methylase	-
KCG54_RS10650 (KCG54_10670)	2202319..2202873	+	555	WP_254325024.1	hypothetical protein	-
KCG54_RS10655 (KCG54_10675)	2203199..2203570	+	372	WP_254324152.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2191484..2242907	51423

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (4-75)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10475.94 Da
• Isoelectric Point: 10.0980

>T199585 WP_079453728.1 NZ_CP073115:2199724-2199987 [Neisseria subflava]
VRKHRFTADAAEDLAYWKKHDARKVERIKLLLEDIKANHPKGIGKPEPLRHHKSGLWSRRIDREHRLVYSVDEDTVTVYA
CRYHYER

Nucleotide

• Length: 264 bp

>T199585 NZ_CP097415:2399894-2400211 [Klebsiella pneumoniae]
ATGTTGACTTTTATTGAACTACAAGGTTTCAGTAAGCGACGCCAGGTGCTGTTGCAGGATGATGAATTTCGGGCCTTTCA
GGAAATCCTTATAAACGATCCCGAGGCTGGGGACACAATTTCGGGAACCGGTGGTTTTCGTAAAATTCGCTGGAGTCGTC
CCGGGATGGGGAAGCGCGGCGGTGTACGAGTGATTTACTATAATGTAACGAAAAAGGGAAGAATTTACCTGGCGCTCATC
TATCCTAAAAATGAACAGGATGAGTTAAATCAGGAGCAAAAAAAGATGTTGAGACAAGTGGCTGATTTAATAAACTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9233.33 Da
• Isoelectric Point: 4.0737

>AT199585 WP_223169026.1 NZ_CP073115:2199479-2199727 [Neisseria subflava]
MDYVISYTAAREDLAQVMTKVCEDQVVTHITRRNGGNCVLMSEEEYSSIMETLYLFGNPTNAARLEHSLAQAEQGEFVEV
DL

Nucleotide

• Length: 249 bp

>AT199585 NZ_CP097415:2400287-2400583 [Klebsiella pneumoniae]
ATGAAAGACGAATTGTTTGCCGATCTGCTGGCGAGTGCAGAAGAAATGGTCAGGATCGAGAAAGGTGAACAAATGCTGAT
GGAGCAGCACGTTCATACCTTCAGCGAAATTGACGTGAAAGCGATACGTGAAGCCACAGGTTTAAAACAGCAGGACTTTG
CAGCGGCCGTTGGCGTTAGCTACGAGTTGGTTAAAAGCTGGGAAACGAAACGACGTCACCCAACCGGTGCAGCCAGAAAG
CTGCTTTTATTGCTTCAGGGTAATCCATTGATTATCAACTTGTTGAAGGTTGTTTGA