Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 976726..977363 Replicon chromosome
Accession NZ_CP073111
Organism Agrobacterium rhizogenes strain A4

Toxin (Protein)


Gene name vapC Uniprot ID A0A5M8ULE8
Locus tag EML492_RS24175 Protein ID WP_034515896.1
Coordinates 976962..977363 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B9JLI6
Locus tag EML492_RS24170 Protein ID WP_007702100.1
Coordinates 976726..976962 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EML492_RS24155 (EML492_24155) 971958..972608 - 651 WP_034515893.1 TetR/AcrR family transcriptional regulator -
EML492_RS24160 (EML492_24160) 972735..974024 + 1290 WP_034515894.1 MFS transporter -
EML492_RS24165 (EML492_24165) 974098..976554 + 2457 WP_034515895.1 beta-glucosidase -
EML492_RS24170 (EML492_24170) 976726..976962 + 237 WP_007702100.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
EML492_RS24175 (EML492_24175) 976962..977363 + 402 WP_034515896.1 type II toxin-antitoxin system VapC family toxin Toxin
EML492_RS24180 (EML492_24180) 977490..978587 - 1098 WP_015917978.1 branched-chain amino acid aminotransferase -
EML492_RS24185 (EML492_24185) 978737..979651 - 915 WP_034515897.1 DUF1194 domain-containing protein -
EML492_RS24190 (EML492_24190) 979671..980288 - 618 WP_015917976.1 LysE family translocator -
EML492_RS24195 (EML492_24195) 980510..981169 - 660 WP_007702087.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-117)

Antitoxin

SpoVT-AbrB domain

(7-46)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14951.22 Da        Isoelectric Point: 5.6421

>T199584 WP_034515896.1 NZ_CP073111:976962-977363 [Agrobacterium rhizogenes]
MPRYMLDTNMCIYLMKNQPEQVARRFAACYVGDVVMSAITFAELDYGVAASDAPERERGNLDALVTLIAVEPFDIAAAHA
YGPVRMATRERKKDHLDKLIASHAIALNTVLVTNNTRDFMAYPNLKIENWLDT

Download         Length: 402 bp

>T199584 NZ_CP097415:1925889-1925991 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9020.18 Da        Isoelectric Point: 4.6561

>AT199584 WP_007702100.1 NZ_CP073111:976726-976962 [Agrobacterium rhizogenes]
MQMTKAFKNGNSQAVRIPAEIAYERTDMELEIERVGDEIRIRPVRQSLAGVMDVFARFSPNFMSEGRGDQEQDEREKI

Download         Length: 237 bp

>AT199584 NZ_CP097415:c1925998-1925853 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M8ULE8

Antitoxin

Source ID Structure
AlphaFold DB A0A5M8UQQ5

References