Detailed information of TA system TA199583

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 387950..388497
• Replicon: chromosome
• Accession: NZ_CP073111
• Organism: Agrobacterium rhizogenes strain A4

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: EML492_RS21705
• Protein ID: WP_034522325.1
• Coordinates: 388204..388497 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: B9JNC7
• Locus tag: EML492_RS21700
• Protein ID: WP_012649398.1
• Coordinates: 387950..388204 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EML492_RS21675 (EML492_21675)	383365..383676	-	312	WP_012649393.1	hypothetical protein	-
EML492_RS21680 (EML492_21680)	383805..385739	-	1935	WP_034522628.1	heavy metal translocating P-type ATPase	-
EML492_RS21685 (EML492_21685)	386150..386449	+	300	WP_034522626.1	hypothetical protein	-
EML492_RS21690 (EML492_21690)	386461..386889	+	429	WP_034522328.1	universal stress protein	-
EML492_RS33895	387445..387582	-	138	WP_229202704.1	hypothetical protein	-
EML492_RS21700 (EML492_21700)	387950..388204	+	255	WP_012649398.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
EML492_RS21705 (EML492_21705)	388204..388497	+	294	WP_034522325.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EML492_RS21710 (EML492_21710)	388865..389932	+	1068	WP_229202671.1	nucleotidyltransferase family protein	-
EML492_RS21715 (EML492_21715)	389929..391017	-	1089	WP_234786743.1	transporter	-
EML492_RS21720 (EML492_21720)	391029..391253	-	225	WP_007689697.1	hypothetical protein	-
EML492_RS21725 (EML492_21725)	391835..392056	+	222	WP_007689698.1	hypothetical protein	-
EML492_RS21730 (EML492_21730)	392246..392710	+	465	WP_012649402.1	VOC family protein	-
EML492_RS21735 (EML492_21735)	392739..393077	-	339	WP_007689700.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-92)

Antitoxin

• Antitoxin ParD (3-70)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11255.84 Da
• Isoelectric Point: 5.5517

>T199583 WP_034522325.1 NZ_CP073111:388204-388497 [Agrobacterium rhizogenes]
MRFSLFVEAEEDIIAIAEQGVRLFGSVQARRYHDELFSLLDLIAANPRMAREREEISPPVRIHPFKAHLVVYRIEEDGAI
FVIRIRHGHEDWASDSV

Nucleotide

• Length: 294 bp

>T199583 NZ_CP097415:794520-794930 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9362.53 Da
• Isoelectric Point: 8.5688

>AT199583 WP_012649398.1 NZ_CP073111:387950-388204 [Agrobacterium rhizogenes]
MATMNVSLPDPMKDWVEAQAKTGRYSNASDYVRDLIRRDQVRSDKIAAMQRFVDDGLKSGVGGRSKDELFATAIAHGEMT
RGDR

Nucleotide

• Length: 255 bp

>AT199583 NZ_CP097415:794273-794539 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A5M8UM94