Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3997904..3998538 Replicon chromosome
Accession NZ_CP073110
Organism Agrobacterium rhizogenes strain A4

Toxin (Protein)


Gene name vapC Uniprot ID B9J7R8
Locus tag EML492_RS19875 Protein ID WP_012650858.1
Coordinates 3997904..3998299 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B9J7R9
Locus tag EML492_RS19880 Protein ID WP_007702738.1
Coordinates 3998296..3998538 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EML492_RS19845 (EML492_19845) 3992919..3993374 + 456 WP_007702750.1 ester cyclase -
EML492_RS19850 (EML492_19850) 3993437..3994201 - 765 WP_007702749.1 SDR family oxidoreductase -
EML492_RS19855 (EML492_19855) 3994321..3995226 + 906 WP_007702748.1 LysR family transcriptional regulator -
EML492_RS19860 (EML492_19860) 3995227..3996102 - 876 WP_007702747.1 LysR family transcriptional regulator -
EML492_RS19865 (EML492_19865) 3996200..3997483 + 1284 WP_034520082.1 MFS transporter -
EML492_RS19870 (EML492_19870) 3997506..3997907 + 402 WP_012650857.1 VOC family protein -
EML492_RS19875 (EML492_19875) 3997904..3998299 - 396 WP_012650858.1 type II toxin-antitoxin system VapC family toxin Toxin
EML492_RS19880 (EML492_19880) 3998296..3998538 - 243 WP_007702738.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
EML492_RS19885 (EML492_19885) 3998607..3999284 - 678 WP_034520085.1 hypothetical protein -
EML492_RS19890 (EML492_19890) 3999355..4001016 - 1662 WP_007702732.1 urocanate hydratase -
EML492_RS19895 (EML492_19895) 4001040..4001369 - 330 WP_007702728.1 TfoX/Sxy family protein -
EML492_RS19900 (EML492_19900) 4001385..4002485 - 1101 WP_007702725.1 DUF917 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-121)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14662.84 Da        Isoelectric Point: 6.8818

>T199582 WP_012650858.1 NZ_CP073110:c3998299-3997904 [Agrobacterium rhizogenes]
VKYLLDSNAVIALMKGHSGFVAEIRKHKPQDFAIPAIVAHELFYGAYKGQRVADNLARVDALQFETLDFDREDARKAGEI
RAALAILGTPIGAYDVLIAGQAVARDLILVTHNVREFQRVKNLRFEDWETV

Download         Length: 396 bp

>T199582 NZ_CP097415:349413-349760 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9333.46 Da        Isoelectric Point: 4.1849

>AT199582 WP_007702738.1 NZ_CP073110:c3998538-3998296 [Agrobacterium rhizogenes]
MDTAKIFWSGRSQAVRLPKEFRFDTDAVRIRRQGQAIILEPIVEDWDWLETVTGPVDQDFAEAATEQPVEQERPELDIFK

Download         Length: 243 bp

>AT199582 NZ_CP097415:349760-350059 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M8UNI2

Antitoxin

Source ID Structure
AlphaFold DB A0A5M8UM92

References