Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbE-relB/ParE-YafN
Location 3032701..3033220 Replicon chromosome
Accession NZ_CP073110
Organism Agrobacterium rhizogenes strain A4

Toxin (Protein)


Gene name stbE Uniprot ID B9JBR9
Locus tag EML492_RS15205 Protein ID WP_012652581.1
Coordinates 3032939..3033220 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B9JBR8
Locus tag EML492_RS15200 Protein ID WP_012652580.1
Coordinates 3032701..3032949 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EML492_RS15175 (EML492_15175) 3028390..3029337 + 948 WP_012652575.1 ABC transporter permease -
EML492_RS15180 (EML492_15180) 3029422..3030129 + 708 WP_007693617.1 YdcF family protein -
EML492_RS15185 (EML492_15185) 3030228..3031028 + 801 WP_012652577.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
EML492_RS15190 (EML492_15190) 3031025..3031558 - 534 WP_012652578.1 gamma-glutamylcyclotransferase -
EML492_RS15195 (EML492_15195) 3031610..3032623 + 1014 WP_034521567.1 DUF2125 domain-containing protein -
EML492_RS15200 (EML492_15200) 3032701..3032949 + 249 WP_012652580.1 antitoxin Antitoxin
EML492_RS15205 (EML492_15205) 3032939..3033220 + 282 WP_012652581.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EML492_RS15210 (EML492_15210) 3033267..3034196 - 930 WP_034521570.1 prephenate/arogenate dehydrogenase family protein -
EML492_RS15215 (EML492_15215) 3034193..3035302 - 1110 WP_012652583.1 histidinol-phosphate transaminase -
EML492_RS15220 (EML492_15220) 3035406..3036185 - 780 WP_007693610.1 class I SAM-dependent methyltransferase -
EML492_RS15225 (EML492_15225) 3036241..3037011 + 771 WP_007693609.1 hydroxyacylglutathione hydrolase -
EML492_RS15230 (EML492_15230) 3037011..3037436 + 426 WP_034521573.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11040.85 Da        Isoelectric Point: 10.6226

>T199580 WP_012652581.1 NZ_CP073110:3032939-3033220 [Agrobacterium rhizogenes]
MTYELGFLHAALKEWRKLDANTREQFKKKLAERCENPRVPSAKLFGSKDRYKIKLRGVGYRLVYEVRDEQLVIIVVAVGK
RERNEVYRAADRR

Download         Length: 282 bp

>T199580 NZ_CP073110:3032939-3033220 [Agrobacterium rhizogenes]
ATGACCTATGAGCTGGGCTTTCTGCATGCCGCTTTAAAAGAGTGGCGAAAGCTCGATGCCAATACGCGGGAGCAATTTAA
GAAGAAGCTTGCCGAGCGCTGCGAAAACCCGCGAGTACCGTCCGCCAAACTTTTCGGAAGCAAAGACCGGTACAAGATCA
AATTGCGCGGCGTCGGCTATCGGCTTGTCTATGAAGTTCGCGACGAGCAGCTCGTGATTATCGTCGTGGCTGTCGGGAAG
AGAGAGCGAAACGAAGTTTATAGAGCTGCCGATAGGCGCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8775.18 Da        Isoelectric Point: 4.3466

>AT199580 WP_012652580.1 NZ_CP073110:3032701-3032949 [Agrobacterium rhizogenes]
MTNVILAEVTASVSELKKNPMGTVAAGEGATVAILNRNAPAFYCVPARLYEAMLDRLEDMELNAIADARAGEPIIKVKLD
DL

Download         Length: 249 bp

>AT199580 NZ_CP073110:3032701-3032949 [Agrobacterium rhizogenes]
ATGACAAATGTAATTCTCGCTGAAGTGACCGCCAGCGTATCGGAATTGAAAAAGAACCCAATGGGAACCGTGGCAGCCGG
CGAAGGGGCGACGGTTGCTATTCTCAACAGGAATGCGCCTGCATTCTATTGTGTCCCGGCCCGCCTCTATGAAGCGATGC
TGGATCGTCTTGAGGATATGGAACTCAACGCCATCGCCGACGCGCGTGCGGGCGAGCCCATCATCAAGGTCAAGCTGGAT
GACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M8UJZ0

Antitoxin

Source ID Structure
AlphaFold DB A0A5M8UL61

References