Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-RelB
Location 836107..836620 Replicon chromosome
Accession NZ_CP073101
Organism Exiguobacterium alkaliphilum strain B-3531D

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag KB235_RS04465 Protein ID WP_034814603.1
Coordinates 836354..836620 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KB235_RS04460 Protein ID WP_034814602.1
Coordinates 836107..836361 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB235_RS04435 (KB235_04435) 831294..831701 + 408 WP_211780520.1 Lrp/AsnC family transcriptional regulator -
KB235_RS04440 (KB235_04440) 831740..832459 - 720 WP_034809901.1 GntR family transcriptional regulator -
KB235_RS04445 (KB235_04445) 832605..833954 + 1350 WP_211780521.1 6-phospho-alpha-glucosidase -
KB235_RS04450 (KB235_04450) 834026..835579 + 1554 WP_211780522.1 PTS transporter subunit EIIC -
KB235_RS04455 (KB235_04455) 835627..835899 - 273 WP_211780523.1 hypothetical protein -
KB235_RS04460 (KB235_04460) 836107..836361 + 255 WP_034814602.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
KB235_RS04465 (KB235_04465) 836354..836620 + 267 WP_034814603.1 Txe/YoeB family addiction module toxin Toxin
KB235_RS04470 (KB235_04470) 836655..837545 - 891 WP_211780524.1 WYL domain-containing protein -
KB235_RS04475 (KB235_04475) 837621..838139 + 519 WP_211780525.1 dihydrofolate reductase family protein -
KB235_RS04480 (KB235_04480) 838176..839681 - 1506 WP_211780526.1 gluconokinase -
KB235_RS04485 (KB235_04485) 839693..841036 - 1344 WP_211780527.1 gluconate:H+ symporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10683.28 Da        Isoelectric Point: 9.7949

>T199575 WP_034814603.1 NZ_CP073101:836354-836620 [Exiguobacterium alkaliphilum]
MSKSLLFTDNGWEDYLYWQKEDKKKLKRINLLIEDVRRNGNLNGIGKPEALKGNLQGFYSRRIDSEHRLVYRVMNQYVEI
LQCRYHYL

Download         Length: 267 bp

>T199575 NZ_CP097411:c4683761-4683228 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9851.08 Da        Isoelectric Point: 4.5670

>AT199575 WP_034814602.1 NZ_CP073101:836107-836361 [Exiguobacterium alkaliphilum]
MSTITYSDARKNFKKVLDQVHENSEAIVISRKNSENAVIMSEQEYESLMETIYLLRSPKNAERLLESIKQIENNEVTERE
LMNE

Download         Length: 255 bp

>AT199575 NZ_CP097411:c4684038-4683772 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References