Detailed information of TA system TA199574

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 4490214..4490770
• Replicon: chromosome
• Accession: NZ_CP073100
• Organism: Luteolibacter ambystomatis strain 32A

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KBB96_RS17330
• Protein ID: WP_211630753.1
• Coordinates: 4490459..4490770 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KBB96_RS17325
• Protein ID: WP_211630752.1
• Coordinates: 4490214..4490471 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KBB96_RS17305 (KBB96_17305)	4486205..4487050	+	846	WP_211630748.1	AraC family transcriptional regulator	-
KBB96_RS17310 (KBB96_17310)	4487052..4487729	-	678	WP_211630749.1	tRNA (guanosine(37)-N1)-methyltransferase TrmD	-
KBB96_RS17315 (KBB96_17315)	4487806..4489011	-	1206	WP_211630750.1	TFIIB-type zinc ribbon-containing protein	-
KBB96_RS17320 (KBB96_17320)	4488992..4490062	-	1071	WP_226373571.1	SPFH domain-containing protein	-
KBB96_RS17325 (KBB96_17325)	4490214..4490471	+	258	WP_211630752.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KBB96_RS17330 (KBB96_17330)	4490459..4490770	+	312	WP_211630753.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KBB96_RS17335 (KBB96_17335)	4491005..4492693	+	1689	WP_211630754.1	sulfatase-like hydrolase/transferase	-
KBB96_RS17340 (KBB96_17340)	4492730..4494466	+	1737	WP_211630755.1	TIGR02597 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11919.90 Da
• Isoelectric Point: 8.0102

>T199574 WP_211630753.1 NZ_CP073100:4490459-4490770 [Luteolibacter ambystomatis]
MAEVIWTEPALADLDAIAEYIALDKLDAARRFVKRVFKRVEQLASFPEAGSFIPEMRPLKVHRQVVVAPCRIFYRFDTSA
DIVRIVGVMRGERLFRPENLDRD

Nucleotide

• Length: 312 bp

>T199574 NZ_CP097411:4041922-4042140 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9567.09 Da
• Isoelectric Point: 7.2045

>AT199574 WP_211630752.1 NZ_CP073100:4490214-4490471 [Luteolibacter ambystomatis]
MKTELATTLKRETNRILTELADARDPVLITQHGLPAAYLVDVGTFEAIQQKLEVLEIIARGEKAVDEGRVVTHKAAEQRM
ARWLK

Nucleotide

• Length: 258 bp

>AT199574 NZ_CP097411:4041521-4041895 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG