Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 166827..167743 Replicon plasmid pWTJH17
Accession NZ_CP073083
Organism Pseudomonas aeruginosa strain WTJH17

Toxin (Protein)


Gene name slvT Uniprot ID A0A212BIN6
Locus tag KCG37_RS30200 Protein ID WP_021018402.1
Coordinates 166827..167351 (-) Length 175 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A2I0C738
Locus tag KCG37_RS30205 Protein ID WP_010792483.1
Coordinates 167348..167743 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KCG37_RS30180 (KCG37_30180) 162144..163289 + 1146 WP_021018404.1 glycerate kinase -
KCG37_RS30185 (KCG37_30185) 163711..163902 - 192 WP_010792486.1 hypothetical protein -
KCG37_RS30190 (KCG37_30190) 164279..165334 + 1056 WP_021018403.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
KCG37_RS30195 (KCG37_30195) 165531..166781 + 1251 WP_010792484.1 TerD family protein -
KCG37_RS30200 (KCG37_30200) 166827..167351 - 525 WP_021018402.1 RES family NAD+ phosphorylase Toxin
KCG37_RS30205 (KCG37_30205) 167348..167743 - 396 WP_010792483.1 hypothetical protein Antitoxin
KCG37_RS30210 (KCG37_30210) 167953..169887 - 1935 WP_010792482.1 hypothetical protein -
KCG37_RS30215 (KCG37_30215) 171196..171720 + 525 WP_010792479.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaCARB-4 / qnrVC1 / sul1 / qacE / aadA1 / cmlA1 / aac(6')-Il / blaNDM-14 / dfrA27 / ARR-3 / blaOXA-246 / aac(6')-IIa / mph(E) / msr(E) - 1..436486 436486


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(10-167)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19011.47 Da        Isoelectric Point: 4.4540

>T199571 WP_021018402.1 NZ_CP073083:c167351-166827 [Pseudomonas aeruginosa]
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQGSAFLPPGLLVSYSLSLDRVI
DFTGGYDDTWAPIWQDFFCDWRKIRFNDGVEPPSWIVGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP

Download         Length: 525 bp

>T199571 NZ_CP097411:1927470-1927572 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14810.93 Da        Isoelectric Point: 7.2048

>AT199571 WP_010792483.1 NZ_CP073083:c167743-167348 [Pseudomonas aeruginosa]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFNYKTAEEVVSEGKTEQLIAFLQSWEAGAQG

Download         Length: 396 bp

>AT199571 NZ_CP097411:c1927579-1927434 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A212BIN6

Antitoxin

Source ID Structure
AlphaFold DB A0A2I0C738

References