Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 142014..142519 Replicon chromosome
Accession NZ_CP073082
Organism Pseudomonas aeruginosa strain WTJH17

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag KCG37_RS00645 Protein ID WP_003121619.1
Coordinates 142014..142295 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag KCG37_RS00650 Protein ID WP_003112628.1
Coordinates 142292..142519 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KCG37_RS00620 (KCG37_00620) 137265..138614 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
KCG37_RS00625 (KCG37_00625) 138663..139349 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
KCG37_RS00630 (KCG37_00630) 139450..140184 + 735 WP_003117208.1 GntR family transcriptional regulator -
KCG37_RS00635 (KCG37_00635) 140364..140774 + 411 WP_003101225.1 aegerolysin family protein -
KCG37_RS00640 (KCG37_00640) 140806..141714 - 909 WP_003083769.1 LysR family transcriptional regulator -
KCG37_RS00645 (KCG37_00645) 142014..142295 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
KCG37_RS00650 (KCG37_00650) 142292..142519 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
KCG37_RS00655 (KCG37_00655) 142695..143315 - 621 WP_003101226.1 hypothetical protein -
KCG37_RS00660 (KCG37_00660) 143416..143916 + 501 WP_003112629.1 LEA type 2 family protein -
KCG37_RS00665 (KCG37_00665) 143989..144330 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
KCG37_RS00670 (KCG37_00670) 144412..145839 - 1428 WP_003121620.1 GABA permease -
KCG37_RS00675 (KCG37_00675) 146008..147501 - 1494 WP_031653061.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T199565 WP_003121619.1 NZ_CP073082:c142295-142014 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T199565 NZ_CP097388:c38439-38023 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCCGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT199565 WP_003112628.1 NZ_CP073082:c142519-142292 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT199565 NZ_CP097388:c38666-38436 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGAGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References