Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 150488..151404 Replicon plasmid pNDTH9845
Accession NZ_CP073081
Organism Pseudomonas aeruginosa strain NDTH9845

Toxin (Protein)


Gene name slvT Uniprot ID A0A2L1KI32
Locus tag KCG38_RS34105 Protein ID WP_019437783.1
Coordinates 150488..151012 (-) Length 175 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A2L1KH13
Locus tag KCG38_RS34110 Protein ID WP_019437782.1
Coordinates 151009..151404 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KCG38_RS34085 (KCG38_34085) 146340..146954 + 615 Protein_144 glycerate kinase -
KCG38_RS34090 (KCG38_34090) 147374..147565 - 192 WP_019437785.1 hypothetical protein -
KCG38_RS34095 (KCG38_34095) 147940..148995 + 1056 WP_139139567.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
KCG38_RS34100 (KCG38_34100) 149192..150442 + 1251 WP_019437784.1 TerD family protein -
KCG38_RS34105 (KCG38_34105) 150488..151012 - 525 WP_019437783.1 RES family NAD+ phosphorylase Toxin
KCG38_RS34110 (KCG38_34110) 151009..151404 - 396 WP_019437782.1 hypothetical protein Antitoxin
KCG38_RS34115 (KCG38_34115) 151988..153871 - 1884 WP_223819158.1 helicase -
KCG38_RS34120 (KCG38_34120) 154071..154325 + 255 WP_021263738.1 hypothetical protein -
KCG38_RS34125 (KCG38_34125) 155219..155743 + 525 WP_010794447.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid qnrVC1 / ARR-3 / dfrA22 / qacE / sul1 / mph(E) / msr(E) / cmlA1 / aac(6')-Il / blaNDM-14 / dfrA27 / blaOXA-246 / aac(6')-IIa - 1..463517 463517


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(10-167)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19052.57 Da        Isoelectric Point: 4.5535

>T199564 WP_019437783.1 NZ_CP073081:c151012-150488 [Pseudomonas aeruginosa]
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQASAFLPPGLLISYSLSLDRVI
DFTGGYNDTWAPIWQDFFCDWRKIRFNDGVEPPSWIIGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP

Download         Length: 525 bp

>T199564 NZ_CP097388:25692-26015 [Klebsiella pneumoniae]
ATGAACTATCTGGAGTTTGTTGAAACCAGCGCTTTCAGTGGACTGCGTAAGGAACTCATGGATGATGATGAATTCCGCGA
ACTGCAGACCTATTTACTGGAAGCCCATGATCGGGGTGACACCATCAGTCATACCGGTGGATGCAGGAAGATTCGCTGGG
GTCGCCCGGGGATGGGTAAGCGAGGTGGCGTCAGGGTGATTTACTACGTTCGTCTTGCCAGCGGCAGACTGTATCTGCTG
CTGATATACCCGAAGAATGCGAAAGATGAGCTCAGCGAGAAAGAAAAAGCCGTTATGAAGGCATTAACACAGCAGCTGAA
GTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14753.87 Da        Isoelectric Point: 7.2048

>AT199564 WP_019437782.1 NZ_CP073081:c151404-151009 [Pseudomonas aeruginosa]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFGYKTAEEVVSEGKTEQLIAFLQSWEAGAQG

Download         Length: 396 bp

>AT199564 NZ_CP097388:26064-26366 [Klebsiella pneumoniae]
ATGGAAAAGAAACTTTTTGATGCCCTGATCAGCAGCATGGAGGAAATGGTGGCCATTGAAAATGGCCAGATCCAGCCCGC
TGCAGAACAGGTTCACCGCCATACACTGCCGGATGTGAAAGCCATTCGTAAACATGCCGGCATGAAACAGGCTGAATTTG
CAGAAGTGGTGGGGGCCAGCGTTGACCTTGTTCGCAGCTGGGAACAGCAACGGCGTGTTCCGTCGGGTATTGCGCTGAAA
ATGCTCTGCCTCATCGAGCGTGAGCCTGCACTGATTAATACGTTGCGTGGTATTCACGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L1KI32

Antitoxin

Source ID Structure
AlphaFold DB A0A2L1KH13

References