Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4787269..4787909 Replicon chromosome
Accession NZ_CP073080
Organism Pseudomonas aeruginosa strain NDTH9845

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KCG38_RS22365 Protein ID WP_003134109.1
Coordinates 4787269..4787679 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KCG38_RS22370 Protein ID WP_031634724.1
Coordinates 4787679..4787909 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KCG38_RS22320 (KCG38_22320) 4782305..4783630 + 1326 WP_191519258.1 STY4528 family pathogenicity island replication protein -
KCG38_RS36165 4783627..4784139 + 513 WP_249170383.1 hypothetical protein -
KCG38_RS22335 (KCG38_22335) 4784296..4785024 + 729 WP_009315862.1 TIGR03761 family integrating conjugative element protein -
KCG38_RS22340 (KCG38_22340) 4785030..4785560 + 531 WP_211851974.1 DUF3158 family protein -
KCG38_RS22345 (KCG38_22345) 4785574..4786062 + 489 WP_023104904.1 single-stranded DNA-binding protein -
KCG38_RS22350 (KCG38_22350) 4786561..4786758 + 198 WP_191519259.1 CrpP family ICE-associated protein -
KCG38_RS22355 (KCG38_22355) 4786824..4787042 - 219 WP_023083218.1 hypothetical protein -
KCG38_RS22360 (KCG38_22360) 4787092..4787253 - 162 WP_191519260.1 hypothetical protein -
KCG38_RS22365 (KCG38_22365) 4787269..4787679 - 411 WP_003134109.1 tRNA(fMet)-specific endonuclease VapC Toxin
KCG38_RS22370 (KCG38_22370) 4787679..4787909 - 231 WP_031634724.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
KCG38_RS22375 (KCG38_22375) 4788227..4790152 + 1926 WP_191519261.1 type I DNA topoisomerase -
KCG38_RS22380 (KCG38_22380) 4790166..4790912 + 747 WP_223723588.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-33)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15452.78 Da        Isoelectric Point: 7.3233

>T199560 WP_003134109.1 NZ_CP073080:c4787679-4787269 [Pseudomonas aeruginosa]
MLKFMLDTNICIFTIKNRPQEVREAFLRHHDQMCISTVTLMELIYGAEKSSNPSRNLADVEGFAARLEVLKYDQEAAAHT
GQLRAELARLGKQIGPYDQMIAGHARSQGLIVVTNNRREFDRVPGLRVEDWVTPIV

Download         Length: 411 bp

>T199560 NZ_CP097385:3962404-3962506 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8420.29 Da        Isoelectric Point: 4.2821

>AT199560 WP_031634724.1 NZ_CP073080:c4787909-4787679 [Pseudomonas aeruginosa]
VEQGSVFQSNRSQAVRLPKAVALPDDVKRVDVVAVGRARIITPAGESWDSWFDGEGVTADFMAEREQPADQERETF

Download         Length: 231 bp

>AT199560 NZ_CP097385:c3962513-3962368 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References