Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_19(antitoxin) |
| Location | 340473..341261 | Replicon | chromosome |
| Accession | NZ_CP073065 | ||
| Organism | Staphylococcus aureus strain 17Gst354 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | KCG41_RS01510 | Protein ID | WP_212593067.1 |
| Coordinates | 340473..340934 (-) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0E7YIA0 |
| Locus tag | KCG41_RS01515 | Protein ID | WP_000333630.1 |
| Coordinates | 340947..341261 (-) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KCG41_RS01485 (337437) | 337437..338642 | - | 1206 | WP_000264185.1 | tyrosine-type recombinase/integrase | - |
| KCG41_RS01490 (338752) | 338752..339366 | + | 615 | WP_000191459.1 | hypothetical protein | - |
| KCG41_RS01495 (339363) | 339363..339509 | - | 147 | WP_001795334.1 | hypothetical protein | - |
| KCG41_RS01500 (339598) | 339598..339993 | - | 396 | WP_001558060.1 | hypothetical protein | - |
| KCG41_RS01505 (340021) | 340021..340455 | - | 435 | WP_119484249.1 | hypothetical protein | - |
| KCG41_RS01510 (340473) | 340473..340934 | - | 462 | WP_212593067.1 | toxin | Toxin |
| KCG41_RS01515 (340947) | 340947..341261 | - | 315 | WP_000333630.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| KCG41_RS01520 (341413) | 341413..341649 | + | 237 | WP_001121027.1 | helix-turn-helix transcriptional regulator | - |
| KCG41_RS01525 (341663) | 341663..342439 | + | 777 | WP_001148544.1 | Rha family transcriptional regulator | - |
| KCG41_RS01530 (342468) | 342468..342617 | + | 150 | WP_000771849.1 | hypothetical protein | - |
| KCG41_RS01535 (342658) | 342658..342870 | - | 213 | WP_000362644.1 | hypothetical protein | - |
| KCG41_RS01540 (342940) | 342940..343137 | + | 198 | WP_001148860.1 | hypothetical protein | - |
| KCG41_RS01545 (343124) | 343124..343504 | - | 381 | WP_000773059.1 | DUF2513 domain-containing protein | - |
| KCG41_RS01550 (343571) | 343571..343816 | + | 246 | WP_001025401.1 | DUF2829 domain-containing protein | - |
| KCG41_RS01555 (343785) | 343785..344150 | - | 366 | WP_016170627.1 | hypothetical protein | - |
| KCG41_RS01560 (344205) | 344205..344420 | + | 216 | WP_001097552.1 | hypothetical protein | - |
| KCG41_RS01565 (344445) | 344445..344708 | + | 264 | WP_001124160.1 | helix-turn-helix domain-containing protein | - |
| KCG41_RS01570 (344721) | 344721..344882 | + | 162 | WP_000048124.1 | DUF1270 family protein | - |
| KCG41_RS01575 (344985) | 344985..345287 | + | 303 | WP_000163429.1 | DUF2482 family protein | - |
| KCG41_RS01580 (345292) | 345292..345552 | + | 261 | WP_031886231.1 | DUF1108 family protein | - |
| KCG41_RS01585 (345562) | 345562..345783 | + | 222 | WP_000815402.1 | DUF2483 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 337437..383359 | 45922 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18046.40 Da Isoelectric Point: 4.6915
>T199536 WP_212593067.1 NZ_CP073065:c340934-340473 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGAWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGAWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T199536 NZ_CP097377:c1678533-1678135 [Actinobacillus pleuropneumoniae]
ATGCTGACTTATATGCTTGATACTAATATTGCGATTTATGTGATTAAACGCAGACCTATTGAAGTGCTGGATAAGTTTAA
TTTAAATTCTACTCGTCTTTGTGTAAGTAGTATCACTGCAGCGGAGCTGTATTATGATGCAGAGAAAAGCCAGTTTCCGG
AACGAAATATGGCAGTAATTGAGGATTTTCTTTCTCGTTTAACAATTCTTGATTATACGCATAAGGCGGCTACTCACTTT
GGCAATATCAAAGCACATTTATCTAAGTGCGGTAAGATTCTCGGCGAGAACGATATTCATATTGCCGCGCATGCAAGAAG
TGAAGGACTCGTATTAGTGACCAATAACTTGCGTGAATTTGAACGTGTGGAAGGATTGCGATTAGATAATTGGGTATAG
ATGCTGACTTATATGCTTGATACTAATATTGCGATTTATGTGATTAAACGCAGACCTATTGAAGTGCTGGATAAGTTTAA
TTTAAATTCTACTCGTCTTTGTGTAAGTAGTATCACTGCAGCGGAGCTGTATTATGATGCAGAGAAAAGCCAGTTTCCGG
AACGAAATATGGCAGTAATTGAGGATTTTCTTTCTCGTTTAACAATTCTTGATTATACGCATAAGGCGGCTACTCACTTT
GGCAATATCAAAGCACATTTATCTAAGTGCGGTAAGATTCTCGGCGAGAACGATATTCATATTGCCGCGCATGCAAGAAG
TGAAGGACTCGTATTAGTGACCAATAACTTGCGTGAATTTGAACGTGTGGAAGGATTGCGATTAGATAATTGGGTATAG
Antitoxin
Download Length: 105 a.a. Molecular weight: 12063.56 Da Isoelectric Point: 6.4736
>AT199536 WP_000333630.1 NZ_CP073065:c341261-340947 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
Download Length: 315 bp
>AT199536 NZ_CP097377:c1678763-1678533 [Actinobacillus pleuropneumoniae]
ATGGAAGCATCAGTATTTATGACAAATCGTAGTCAAGCGGTACGATTGCCGGCAGAAGTACGTTTTGCAAGTGATGTAAA
AAAACTTTCTGTAAGAGTAGTTGGTAATGAGCGTATTTTGGCACCGATTAACCAAAGTTGGGATAGCTTCTTTCTAAGTT
CGGCAACGGTAAGCGATGATTTTATGACAGAGCGTGAAATAAGCACTCAAGCTGAACGTGAGGAACTGTAA
ATGGAAGCATCAGTATTTATGACAAATCGTAGTCAAGCGGTACGATTGCCGGCAGAAGTACGTTTTGCAAGTGATGTAAA
AAAACTTTCTGTAAGAGTAGTTGGTAATGAGCGTATTTTGGCACCGATTAACCAAAGTTGGGATAGCTTCTTTCTAAGTT
CGGCAACGGTAAGCGATGATTTTATGACAGAGCGTGAAATAAGCACTCAAGCTGAACGTGAGGAACTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|