Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 476743..477396 Replicon chromosome
Accession NZ_CP073060
Organism Acinetobacter baumannii strain DETAB-P39

Toxin (Protein)


Gene name cptA Uniprot ID A0A2S4T466
Locus tag J7D36_RS02350 Protein ID WP_000607071.1
Coordinates 477007..477396 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag J7D36_RS02345 Protein ID WP_001288210.1
Coordinates 476743..477000 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J7D36_RS02325 (J7D36_02325) 472258..473265 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
J7D36_RS02330 (J7D36_02330) 473284..473661 + 378 WP_001216380.1 50S ribosomal protein L17 -
J7D36_RS02335 (J7D36_02335) 473843..475333 + 1491 WP_000415137.1 NAD(P)/FAD-dependent oxidoreductase -
J7D36_RS02340 (J7D36_02340) 475383..476555 - 1173 WP_021510118.1 acyl-CoA dehydrogenase family protein -
J7D36_RS02345 (J7D36_02345) 476743..477000 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
J7D36_RS02350 (J7D36_02350) 477007..477396 + 390 WP_000607071.1 membrane protein Toxin
J7D36_RS02355 (J7D36_02355) 478166..479251 + 1086 WP_000049106.1 hypothetical protein -
J7D36_RS02360 (J7D36_02360) 479329..479895 + 567 WP_000651536.1 rhombosortase -
J7D36_RS02365 (J7D36_02365) 480083..482278 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.98 Da        Isoelectric Point: 10.4623

>T199530 WP_000607071.1 NZ_CP073060:477007-477396 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T199530 NZ_CP097374:536409-536759 [Bacillus safensis]
TTGATTGTTAAACGCGGTGATGTTTACTTTGCTGATTTATCTCCTGTTGTTGGCTCCGAGCAGGGCGGGGTTCGCCCAGT
ATTGGTGATTCAAAATGACATTGGAAATCGCTTCAGCCCGACTGCTATCGTTGCAGCCATAACAGCCCAAATACAAAAAG
CGAAATTACCGACTCACGTCGAAATTGATGCAAAGCGCTACGGCTTTGAACGAGATTCTGTCATTCTCTTGGAGCAGATT
CGTACAATCGATAAACAAAGATTGACAGATAAAATCACACATCTTGATGATGAGATGATGGAGAAGGTTGATGAAGCCTT
ACAAGTTAGTTTGGCTCTTATTGATTTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT199530 WP_001288210.1 NZ_CP073060:476743-477000 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT199530 NZ_CP097374:536123-536404 [Bacillus safensis]
TTGTCTGAATCCAGCGCAACAAACGAAATGAAGATTCGACTACCGGAGGCTTTGATGTCTGAAATCGAACGAGTAGCAGA
GCAGGATAAGGTAACAAGAAATGAATTGATCTACCGAGCGACAAAAACGTATATTCGTGAACGCAATATTCGACAAAATC
GTGAATCGATGAGACGCGGCTACATGGAGATGGCGAAAATTAATCTGAATATCTCTTCAGAGGCACAATACGCAGAATTT
GAGGCTGAGAATACAGTTGAGCGATTAGTCAGCGGGGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4T466

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References