Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 355822..356450 Replicon chromosome
Accession NZ_CP073060
Organism Acinetobacter baumannii strain DETAB-P39

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J7D36_RS01675 Protein ID WP_004833671.1
Coordinates 355822..356223 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A158LZG4
Locus tag J7D36_RS01680 Protein ID WP_002125542.1
Coordinates 356223..356450 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J7D36_RS01650 (J7D36_01650) 351487..352374 + 888 WP_021510155.1 metal-dependent hydrolase -
J7D36_RS01655 (J7D36_01655) 352505..353095 + 591 WP_000846931.1 LemA family protein -
J7D36_RS01660 (J7D36_01660) 353117..354199 + 1083 WP_021510154.1 TPM domain-containing protein -
J7D36_RS01665 (J7D36_01665) 354193..354753 + 561 WP_021510153.1 TPM domain-containing protein -
J7D36_RS01670 (J7D36_01670) 355096..355554 + 459 WP_021510152.1 pilin -
J7D36_RS01675 (J7D36_01675) 355822..356223 - 402 WP_004833671.1 type II toxin-antitoxin system VapC family toxin Toxin
J7D36_RS01680 (J7D36_01680) 356223..356450 - 228 WP_002125542.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
J7D36_RS01685 (J7D36_01685) 356603..358231 + 1629 WP_021510151.1 O-antigen ligase family protein -
J7D36_RS01690 (J7D36_01690) 358272..358736 - 465 WP_000678123.1 bacterioferritin -
J7D36_RS01695 (J7D36_01695) 358981..359175 - 195 WP_000289091.1 bacterioferritin-associated ferredoxin -
J7D36_RS01700 (J7D36_01700) 359385..359768 - 384 WP_000090000.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15100.37 Da        Isoelectric Point: 7.2756

>T199529 WP_004833671.1 NZ_CP073060:c356223-355822 [Acinetobacter baumannii]
MLRYMLDTNIVIYTIKNKPPEVKVRFNAVATQLCVSSITVAELIYGAENSQNPIKNLRVVEDFLSRLQILDYTPEAAAQY
GMIKADLRRKGTLISDNDTHIAAHARSHGLILVTNNTKEFQRVEALQLENWVE

Download         Length: 402 bp

>T199529 NZ_CP097373:530361-530711 [Bacillus safensis]
TTGATTGTTAAACGCGGTGATGTTTACTTTGCTGATTTATCTCCTGTTGTTGGCTCCGAGCAGGGCGGGGTTCGCCCAGT
ATTGGTGATTCAAAATGACATTGGAAATCGCTTCAGCCCGACTGCTATCGTTGCAGCCATAACAGCCCAAATACAAAAAG
CGAAATTACCGACTCACGTCGAAATTGATGCAAAGCGCTACGGCTTTGAACGAGATTCTGTCATTCTTTTAGAGCAGATT
CGTACAATCGATAAACAAAGATTGACAGATAAAATCACACATCTTGATGATGAGATGATGGAGAAGGTTGATGAAGCCTT
ACAAGTTAGTTTGGCTCTTATTGATTTTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8706.86 Da        Isoelectric Point: 4.7361

>AT199529 WP_002125542.1 NZ_CP073060:c356450-356223 [Acinetobacter baumannii]
MITSVFTNNRSQAVRLPAIFRFPKETQKVFVRVVGVERVICPVEHIWDSFFDDAQLTVSDDFERGEQIAAERESF

Download         Length: 228 bp

>AT199529 NZ_CP097373:530075-530356 [Bacillus safensis]
TTGTCTGAATCCAGCGCAACAAACGAAATGAAGATTCGACTGCCGGAGGCTTTAATGTCTGAGATCGAACGAGTAGCAGA
GCAGGATAAGGTAACAAGAAATGAATTGATCTACCGAGCGACAAAAACGTATATTCGTGAACGTAATATTCGACAAAATC
GTGAATCGATGAGACGCGGCTACATGGAGATGGCGAAAATTAATCTGAATATCTCTTCAGAGGCACAATACGCAGAATTT
GAGGCTGAGAATACAGTTGAGCGATTAGTCAGCGGGGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A158LZG4

References