Detailed information of TA system TA199524

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-PHD
• Location: 3260958..3261643
• Replicon: chromosome
• Accession: NZ_CP073017
• Organism: Synechocystis sp. PCC 6803

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A6P1VMJ8
• Locus tag: KBZ93_RS15170
• Protein ID: WP_010874101.1
• Coordinates: 3260958..3261353 (-)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KBZ93_RS15175
• Protein ID: WP_010874102.1
• Coordinates: 3261365..3261643 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KBZ93_RS15155 (KBZ93_15160)	3256587..3258782	-	2196	WP_010874098.1	phosphoketolase	-
KBZ93_RS15160 (KBZ93_15165)	3259031..3260170	-	1140	WP_010874099.1	site-2 protease family protein	-
KBZ93_RS15165 (KBZ93_15170)	3260300..3260956	+	657	WP_010874100.1	YggS family pyridoxal phosphate-dependent enzyme	-
KBZ93_RS15170 (KBZ93_15175)	3260958..3261353	-	396	WP_010874101.1	type II toxin-antitoxin system VapC family toxin	Toxin
KBZ93_RS15175 (KBZ93_15180)	3261365..3261643	-	279	WP_010874102.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KBZ93_RS15180 (KBZ93_15185)	3261713..3263056	-	1344	WP_010874103.1	FIST C-terminal domain-containing protein	-
KBZ93_RS15185 (KBZ93_15190)	3263184..3265916	+	2733	WP_010874104.1	valine--tRNA ligase	-
KBZ93_RS15190 (KBZ93_15195)	3266138..3266443	-	306	WP_197525966.1	NADH-quinone oxidoreductase subunit NuoK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 15081.50 Da
• Isoelectric Point: 4.5594

>T199524 WP_010874101.1 NZ_CP073017:c3261353-3260958 [Synechocystis sp. PCC 6803]
VKLLLDTQCWLWWFTEPEKLNEDAISQIIDETNEIWLSVASIWEMSIKTSIGKLPLPENIDDYILSRMVKLGAEFLDIKT
RHALQVATLPLHHRDPFDRIIIAQAQTENMLLISADSMFKNYGVSLLWAGV

Nucleotide

• Length: 396 bp

>T199524 NZ_CP097370:c4035200-4034913 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10084.59 Da
• Isoelectric Point: 4.0201

>AT199524 WP_010874102.1 NZ_CP073017:c3261643-3261365 [Synechocystis sp. PCC 6803]
MIGVSVNPEKLGSTMETVNVDQIEINLPELLYSIKPGEEVIVADQGIPIAKLVPLQRQKSVDRCSSLGVDRGLFVVPDDF
NDPLPNDIWPLS

Nucleotide

• Length: 279 bp

>AT199524 NZ_CP097370:c4034926-4034624 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Structures

Toxin

• AlphaFold DB: A0A6P1VMJ8