Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 2464865..2465453 Replicon chromosome
Accession NZ_CP073015
Organism Flavobacterium sp. CS20

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag IGB25_RS11715 Protein ID WP_211065162.1
Coordinates 2464865..2465167 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag IGB25_RS11720 Protein ID WP_211065163.1
Coordinates 2465169..2465453 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IGB25_RS11700 (IGB25_11700) 2461164..2462428 + 1265 Protein_2336 2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase -
IGB25_RS11705 (IGB25_11705) 2462629..2463753 + 1125 WP_211065160.1 Fic family protein -
IGB25_RS11710 (IGB25_11710) 2464040..2464777 + 738 WP_211065161.1 ComF family protein -
IGB25_RS11715 (IGB25_11715) 2464865..2465167 + 303 WP_211065162.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IGB25_RS11720 (IGB25_11720) 2465169..2465453 + 285 WP_211065163.1 putative addiction module antidote protein Antitoxin
IGB25_RS11725 (IGB25_11725) 2465469..2467121 - 1653 WP_211065164.1 hypothetical protein -
IGB25_RS11730 (IGB25_11730) 2467125..2468621 - 1497 WP_211065165.1 GH3 auxin-responsive promoter family protein -
IGB25_RS11735 (IGB25_11735) 2468621..2469481 - 861 WP_211065166.1 M23 family metallopeptidase -
IGB25_RS11740 (IGB25_11740) 2469650..2469859 - 210 WP_211065167.1 helix-turn-helix transcriptional regulator -
IGB25_RS11745 (IGB25_11745) 2469849..2470316 - 468 WP_211065168.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-84)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11840.82 Da        Isoelectric Point: 10.3343

>T199518 WP_211065162.1 NZ_CP073015:2464865-2465167 [Flavobacterium sp. CS20]
MFFIEKTAEFDKWIRKLKDIRAKSKILFRIQKLETDEHFGDCKPVGDGISEMRINYAKAYRVYFKQKEAKIIILLIGGDK
SSQQKDIERAKNIWNSIKNN

Download         Length: 303 bp

>T199518 NZ_CP097370:2173187-2173289 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10180.90 Da        Isoelectric Point: 8.4453

>AT199518 WP_211065163.1 NZ_CP073015:2465169-2465453 [Flavobacterium sp. CS20]
MKTTKFDIAEYLDNQDMVVEYLNTALEEGGSSDLIVAIGHVAKSIGMSKIAEKTGMSRPSLYKALSEGSKPQFETIMKVL
KAIGGQIKMKPISA

Download         Length: 285 bp

>AT199518 NZ_CP097370:c2173327-2173059 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References