Detailed information of TA system TA199514

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelB-YoeB
• Location: 2911739..2912244
• Replicon: chromosome
• Accession: NZ_CP073013
• Organism: Marinomonas profundi strain M1K-6

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: J8N69_RS13555
• Protein ID: WP_168823199.1
• Coordinates: 2911739..2911993 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: J8N69_RS13560
• Protein ID: WP_168823201.1
• Coordinates: 2911990..2912244 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8N69_RS13550 (J8N69_13515)	2910869..2911318	+	450	WP_211084877.1	DUF5655 domain-containing protein	-
J8N69_RS13555 (J8N69_13520)	2911739..2911993	+	255	WP_168823199.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Toxin
J8N69_RS13560 (J8N69_13525)	2911990..2912244	+	255	WP_168823201.1	Txe/YoeB family addiction module toxin	Antitoxin
J8N69_RS13565 (J8N69_13530)	2912687..2913352	+	666	WP_168823203.1	hypothetical protein	-
J8N69_RS13570 (J8N69_13535)	2913697..2914116	+	420	WP_168823204.1	tetratricopeptide repeat protein	-
J8N69_RS13575 (J8N69_13540)	2914130..2914714	+	585	WP_168823206.1	3'-5' exonuclease	-
J8N69_RS13580 (J8N69_13545)	2914764..2916626	-	1863	WP_168823208.1	GGDEF domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Antitoxin

• Toxin YoeB (1-84)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9340.55 Da
• Isoelectric Point: 4.7815

>T199514 WP_168823199.1 NZ_CP073013:2911739-2911993 [Marinomonas profundi]
MDTLSYSAFRTNLAKTLDKVNDDHKPVIITRQGGKPAVLISLEDFQAYEETAYLMASPKNASRLNEAIAEVNAGKTQVRE
LIEE

Nucleotide

• Length: 255 bp

>T199514 NZ_CP097370:1032359-1032766 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 10293.68 Da
• Isoelectric Point: 8.8012

>AT199514 WP_168823201.1 NZ_CP073013:2911990-2912244 [Marinomonas profundi]
MILSWAESAWSDYLYWQQKDKKTLKRINTLIKDITRQPFEGLGDPEPLKHNWSGYWSRRIDREHRLVYSVEGDTLYIVQC
RYHY

Nucleotide

• Length: 255 bp

>AT199514 NZ_CP097370:1032112-1032378 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA