Detailed information of TA system TA199512

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 2832591..2833168
• Replicon: chromosome
• Accession: NZ_CP073013
• Organism: Marinomonas profundi strain M1K-6

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: J8N69_RS13235
• Protein ID: WP_168823076.1
• Coordinates: 2832869..2833168 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: J8N69_RS13230
• Protein ID: WP_168823073.1
• Coordinates: 2832591..2832872 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8N69_RS13205 (J8N69_13170)	2827666..2828523	+	858	WP_168823061.1	formyltetrahydrofolate deformylase	-
J8N69_RS13210 (J8N69_13175)	2828678..2828938	+	261	WP_168823063.1	formyltetrahydrofolate deformylase	-
J8N69_RS13215 (J8N69_13180)	2829373..2829984	+	612	WP_168823065.1	LysE family translocator	-
J8N69_RS13220 (J8N69_13185)	2830493..2830744	+	252	WP_168823067.1	transposase	-
J8N69_RS13225 (J8N69_13190)	2831352..2832407	+	1056	WP_168823071.1	SH3 domain-containing protein	-
J8N69_RS13230 (J8N69_13195)	2832591..2832872	+	282	WP_168823073.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
J8N69_RS13235 (J8N69_13200)	2832869..2833168	+	300	WP_168823076.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J8N69_RS13240 (J8N69_13205)	2833254..2833748	+	495	WP_168823078.1	ATP-binding protein	-
J8N69_RS13245 (J8N69_13210)	2833886..2834143	+	258	WP_168823080.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
J8N69_RS13250 (J8N69_13215)	2834131..2834433	+	303	WP_168823083.1	type II toxin-antitoxin system RelE/ParE family toxin	-
J8N69_RS13255 (J8N69_13220)	2834523..2834921	+	399	WP_168823084.1	GFA family protein	-
J8N69_RS13260 (J8N69_13225)	2835414..2835899	+	486	WP_168823085.1	DUF3015 domain-containing protein	-
J8N69_RS13265 (J8N69_13230)	2836018..2837898	+	1881	WP_168823087.1	DUF4105 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	2831409..2833748	2339

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-74)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11305.90 Da
• Isoelectric Point: 4.4453

>T199512 WP_168823076.1 NZ_CP073013:2832869-2833168 [Marinomonas profundi]
MKIVWSPLALERVEDIAQYIAEDKPAAAVEWVDGLFATVERLADFPESGRMVPEVGAHRIREVMFGAYRVIYSVRDQIDI
LTVRRSNQLLRASELDDET

Nucleotide

• Length: 300 bp

>T199512 NZ_CP097370:703679-703993 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10648.18 Da
• Isoelectric Point: 7.3196

>AT199512 WP_168823073.1 NZ_CP073013:2832591-2832872 [Marinomonas profundi]
MSRVHVDEDIRPLSEFRAGVATFVKQIHETRRPMVLTQRGRGVAVLVDVQVYERMQERLEVLEEVYKAEEQIASGAGISH
QDAKSWVLSKLSR

Nucleotide

• Length: 282 bp

>AT199512 NZ_CP097370:703990-704406 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA