Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /BrnT(toxin) |
| Location | 2020094..2020580 | Replicon | chromosome |
| Accession | NZ_CP073013 | ||
| Organism | Marinomonas profundi strain M1K-6 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | J8N69_RS09405 | Protein ID | WP_168824016.1 |
| Coordinates | 2020094..2020357 (+) | Length | 88 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | J8N69_RS09410 | Protein ID | WP_168824018.1 |
| Coordinates | 2020347..2020580 (+) | Length | 78 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J8N69_RS09380 (J8N69_09345) | 2015162..2016271 | + | 1110 | WP_168827096.1 | hypothetical protein | - |
| J8N69_RS09385 (J8N69_09350) | 2016392..2016715 | + | 324 | WP_168827677.1 | hypothetical protein | - |
| J8N69_RS09390 (J8N69_09355) | 2016712..2017077 | + | 366 | WP_168827675.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| J8N69_RS09395 (J8N69_09360) | 2017344..2018777 | + | 1434 | Protein_1827 | IS66 family transposase | - |
| J8N69_RS09400 (J8N69_09365) | 2019178..2019960 | + | 783 | WP_168824436.1 | hypothetical protein | - |
| J8N69_RS09405 (J8N69_09370) | 2020094..2020357 | + | 264 | WP_168824016.1 | BrnT family toxin | Toxin |
| J8N69_RS09410 (J8N69_09375) | 2020347..2020580 | + | 234 | WP_168824018.1 | CopG family transcriptional regulator | Antitoxin |
| J8N69_RS09415 (J8N69_09380) | 2020894..2021184 | - | 291 | WP_168824020.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| J8N69_RS09420 (J8N69_09385) | 2021177..2021398 | - | 222 | WP_168824021.1 | hypothetical protein | - |
| J8N69_RS09425 (J8N69_09390) | 2021699..2022205 | + | 507 | WP_168824023.1 | GNAT family N-acetyltransferase | - |
| J8N69_RS09430 (J8N69_09395) | 2022440..2022709 | + | 270 | WP_168824025.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| J8N69_RS09435 (J8N69_09400) | 2022710..2023009 | + | 300 | WP_168824027.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| J8N69_RS09440 (J8N69_09405) | 2023196..2024041 | + | 846 | WP_168824029.1 | arylamine N-acetyltransferase | - |
| J8N69_RS09445 (J8N69_09410) | 2024038..2025012 | + | 975 | WP_168824031.1 | DMT family transporter | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 2016712..2017077 | 365 | |
| - | inside | Integron | - | - | 2019070..2020687 | 1617 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 88 a.a. Molecular weight: 10251.61 Da Isoelectric Point: 8.4846
>T199510 WP_168824016.1 NZ_CP073013:2020094-2020357 [Marinomonas profundi]
MNKFEYDPEKSKSNLEKHGIDFEQAQELWQDSELIEVSVKTTDEPRALVVGKLNKKHWSAIITYRNSNIRIISVRRSRKT
EVVLYES
MNKFEYDPEKSKSNLEKHGIDFEQAQELWQDSELIEVSVKTTDEPRALVVGKLNKKHWSAIITYRNSNIRIISVRRSRKT
EVVLYES
Download Length: 264 bp
>T199510 NZ_CP097370:352156-352683 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA
Antitoxin
Download Length: 78 a.a. Molecular weight: 9108.28 Da Isoelectric Point: 5.6686
>AT199510 WP_168824018.1 NZ_CP073013:2020347-2020580 [Marinomonas profundi]
MKARDFDQKFDANDDDIINDIDLTSVKRVNQQQKRVNVDFPVWMIDSLDKEASRLGVTRQSIIKVWLAERLEHQINH
MKARDFDQKFDANDDDIINDIDLTSVKRVNQQQKRVNVDFPVWMIDSLDKEASRLGVTRQSIIKVWLAERLEHQINH
Download Length: 234 bp
>AT199510 NZ_CP097370:351883-352149 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|