199509

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1831560..1832098 Replicon chromosome
Accession NZ_CP073013
Organism Marinomonas profundi strain M1K-6

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag J8N69_RS08575 Protein ID WP_168825243.1
Coordinates 1831560..1831859 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag J8N69_RS08580 Protein ID WP_168825245.1
Coordinates 1831856..1832098 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8N69_RS08550 (J8N69_08530) 1826716..1827477 + 762 WP_168825235.1 sulfite exporter TauE/SafE family protein -
J8N69_RS08555 (J8N69_08535) 1827542..1829572 - 2031 WP_168825237.1 hypothetical protein -
J8N69_RS08560 (J8N69_08540) 1829977..1830387 + 411 WP_168825239.1 hypothetical protein -
J8N69_RS08565 (J8N69_08545) 1830463..1830939 + 477 WP_168825241.1 hypothetical protein -
J8N69_RS08570 (J8N69_08550) 1831027..1831347 + 321 WP_227803848.1 hypothetical protein -
J8N69_RS08575 (J8N69_08555) 1831560..1831859 - 300 WP_168825243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J8N69_RS08580 (J8N69_08560) 1831856..1832098 - 243 WP_168825245.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
J8N69_RS08585 1832197..1832478 - 282 WP_227803849.1 diguanylate cyclase -
J8N69_RS08590 1832440..1832658 + 219 WP_227803850.1 putative addiction module antidote protein -
J8N69_RS08595 (J8N69_08570) 1832687..1833277 - 591 WP_168825249.1 DNA-3-methyladenine glycosylase I -
J8N69_RS08600 (J8N69_08575) 1833261..1834193 - 933 WP_168825251.1 LysR family transcriptional regulator -
J8N69_RS08605 (J8N69_08580) 1834475..1835506 + 1032 WP_168825252.1 amino acid ABC transporter substrate-binding protein -
J8N69_RS08610 (J8N69_08585) 1835604..1836791 + 1188 WP_168825254.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-91)

Antitoxin

Antitoxin ParD

(1-76)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11565.23 Da        Isoelectric Point: 9.4651

>T199509 WP_168825243.1 NZ_CP073013:c1831859-1831560 [Marinomonas profundi]
MSLFLISRAARGDLKNIAAYTQKTWGTEQRRSYIKELDRTFLFLAENPMSGTPCDYIISGLKKHRHESHTIFYENKDNSI
FIVRVLHKSMDTESQLEKP

Download         Length: 300 bp

>T199509 NZ_CP097370:249645-249752 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGTTCCGGTCATTACTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8736.70 Da        Isoelectric Point: 4.4217

>AT199509 WP_168825245.1 NZ_CP073013:c1832098-1831856 [Marinomonas profundi]
MAKNTSISLGNHFDQFIARQVADGRYGSASEVIRAGLRKLEDDTQKLETLRALIQEGVASGTAEYSYDGLMAELDDELGK

Download         Length: 243 bp

>AT199509 NZ_CP097370:c249588-249531 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References