Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 717076..717626 Replicon chromosome
Accession NZ_CP073013
Organism Marinomonas profundi strain M1K-6

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag J8N69_RS03300 Protein ID WP_168822688.1
Coordinates 717336..717626 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J8N69_RS03295 Protein ID WP_168822690.1
Coordinates 717076..717348 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8N69_RS03270 (J8N69_03255) 712450..712692 + 243 WP_168822703.1 exodeoxyribonuclease VII small subunit -
J8N69_RS03275 (J8N69_03260) 712689..713582 + 894 WP_168822701.1 (2E,6E)-farnesyl diphosphate synthase -
J8N69_RS03280 (J8N69_03265) 713634..715511 + 1878 WP_168822962.1 1-deoxy-D-xylulose-5-phosphate synthase -
J8N69_RS03285 (J8N69_03270) 715747..716403 + 657 WP_168822692.1 5,6-dimethylbenzimidazole synthase -
J8N69_RS03290 (J8N69_03275) 716665..716880 + 216 WP_211084852.1 hypothetical protein -
J8N69_RS03295 (J8N69_03280) 717076..717348 + 273 WP_168822690.1 CopG family ribbon-helix-helix protein Antitoxin
J8N69_RS03300 (J8N69_03285) 717336..717626 + 291 WP_168822688.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J8N69_RS03305 (J8N69_03290) 717784..717984 + 201 WP_168822686.1 hypothetical protein -
J8N69_RS03310 (J8N69_03295) 718108..718881 - 774 WP_168822684.1 cobalamin biosynthesis protein -
J8N69_RS03315 (J8N69_03300) 718878..719618 - 741 WP_168822683.1 precorrin-2 C(20)-methyltransferase -
J8N69_RS03320 (J8N69_03305) 719615..720982 - 1368 WP_227803963.1 precorrin-6y C5,15-methyltransferase (decarboxylating) subunit CbiE -
J8N69_RS03325 (J8N69_03310) 721126..721791 - 666 WP_168822679.1 precorrin-8X methylmutase -
J8N69_RS03330 (J8N69_03315) 721788..722576 - 789 WP_168822677.1 precorrin-6A/cobalt-precorrin-6A reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10968.57 Da        Isoelectric Point: 7.3156

>T199508 WP_168822688.1 NZ_CP073013:717336-717626 [Marinomonas profundi]
MPHLIWSPAALTDVQRIYRFLVQKDEDAAQRAIKTIRAGVKILAHQSKAGRPVEDMDTAFREWLIDFGTSGYIVLYQFDG
ETTTILAMRHQKEAGY

Download         Length: 291 bp

>T199508 NZ_CP097370:249162-249269 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10703.00 Da        Isoelectric Point: 5.9880

>AT199508 WP_168822690.1 NZ_CP073013:717076-717348 [Marinomonas profundi]
MATSVKLDDDLKSRIQHLAEARHRSSHWIMREAIRDYVEREEKRESFKQDALRAWEDYQENGLHLTLEEADTWLAKLEVG
QDVKIPKCHT

Download         Length: 273 bp

>AT199508 NZ_CP097370:c249113-249048 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References