Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VagC |
| Location | 616292..616923 | Replicon | chromosome |
| Accession | NZ_CP073013 | ||
| Organism | Marinomonas profundi strain M1K-6 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | J8N69_RS02830 | Protein ID | WP_269751546.1 |
| Coordinates | 616292..616681 (-) | Length | 130 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | J8N69_RS02835 | Protein ID | WP_168822866.1 |
| Coordinates | 616693..616923 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J8N69_RS02790 (J8N69_02775) | 611915..612769 | - | 855 | WP_227803958.1 | replication protein P | - |
| J8N69_RS02795 (J8N69_02780) | 612678..613493 | - | 816 | WP_168822882.1 | DnaT-like ssDNA-binding domain-containing protein | - |
| J8N69_RS02800 (J8N69_02785) | 613702..614019 | + | 318 | WP_168822880.1 | ribosome-associated translation inhibitor RaiA | - |
| J8N69_RS02805 (J8N69_02790) | 614178..614840 | + | 663 | WP_168822878.1 | Bax inhibitor-1/YccA family protein | - |
| J8N69_RS02810 (J8N69_02795) | 614938..615330 | + | 393 | WP_168822876.1 | sulfurtransferase complex subunit TusD | - |
| J8N69_RS02815 (J8N69_02800) | 615335..615679 | + | 345 | WP_168822874.1 | DsrE family protein | - |
| J8N69_RS02820 (J8N69_02805) | 615682..615969 | + | 288 | WP_168822872.1 | DsrH/TusB family sulfur metabolism protein | - |
| J8N69_RS02825 (J8N69_02810) | 615975..616295 | + | 321 | WP_168822870.1 | TusE/DsrC/DsvC family sulfur relay protein | - |
| J8N69_RS02830 (J8N69_02815) | 616292..616681 | - | 390 | WP_269751546.1 | tRNA(fMet)-specific endonuclease VapC | Toxin |
| J8N69_RS02835 (J8N69_02820) | 616693..616923 | - | 231 | WP_168822866.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| J8N69_RS02840 (J8N69_02825) | 616966..617709 | - | 744 | WP_168822864.1 | uroporphyrinogen-III C-methyltransferase | - |
| J8N69_RS02845 (J8N69_02830) | 617820..619121 | - | 1302 | WP_168822862.1 | serine--tRNA ligase | - |
| J8N69_RS02850 (J8N69_02835) | 619188..619559 | - | 372 | WP_168822860.1 | fluoride efflux transporter CrcB | - |
| J8N69_RS02855 (J8N69_02840) | 619612..620976 | - | 1365 | WP_168822858.1 | replication-associated recombination protein A | - |
| J8N69_RS02860 (J8N69_02845) | 620976..621602 | - | 627 | WP_168822856.1 | outer membrane lipoprotein chaperone LolA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 606928..616923 | 9995 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 130 a.a. Molecular weight: 14248.48 Da Isoelectric Point: 7.2766
>T199507 WP_269751546.1 NZ_CP073013:c616681-616292 [Marinomonas profundi]
MLDTNIAIYTIKNKPKEVREAFKAHDGQMCISIITLMELIYGAEASAAVDRNLREIEGFAARLEVLPYGSDAATHTGQLR
AELKKIGRPIGPYDEMIAGHARSLGLIVVTNNIKQFENAPGIRLVNWVN
MLDTNIAIYTIKNKPKEVREAFKAHDGQMCISIITLMELIYGAEASAAVDRNLREIEGFAARLEVLPYGSDAATHTGQLR
AELKKIGRPIGPYDEMIAGHARSLGLIVVTNNIKQFENAPGIRLVNWVN
Download Length: 390 bp
>T199507 NZ_CP097370:c46336-45959 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTACGAACTGACCAGCCAGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTACGAACTGACCAGCCAGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8644.72 Da Isoelectric Point: 5.0492
>AT199507 WP_168822866.1 NZ_CP073013:c616923-616693 [Marinomonas profundi]
MERASIFKSNKSQALRLPKLVAYPDTVKQVDIVVQGRARIIMPAGESWDTWFDSEGVSADFMSSREEPAHQDRESF
MERASIFKSNKSQALRLPKLVAYPDTVKQVDIVVQGRARIIMPAGESWDTWFDSEGVSADFMSSREEPAHQDRESF
Download Length: 231 bp
>AT199507 NZ_CP097370:c46794-46426 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGAAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGAAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|