Detailed information of TA system TA199506

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): sdenTA/AbiEii(toxin)
• Location: 485092..486508
• Replicon: chromosome
• Accession: NZ_CP073013
• Organism: Marinomonas profundi strain M1K-6

Toxin (Protein)

• Gene name: sdenT
• Uniprot ID: -
• Locus tag: J8N69_RS02195
• Protein ID: WP_168825852.1
• Coordinates: 485618..486508 (+)
• Length: 297 a.a.

Antitoxin (Protein)

• Gene name: sdenA
• Uniprot ID: -
• Locus tag: J8N69_RS02190
• Protein ID: WP_168825850.1
• Coordinates: 485092..485616 (+)
• Length: 175 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8N69_RS02175 (J8N69_02175)	480331..480915	-	585	WP_168825844.1	hypothetical protein	-
J8N69_RS02180 (J8N69_02180)	481285..481866	+	582	WP_168825846.1	HupE/UreJ family protein	-
J8N69_RS02185 (J8N69_02185)	482001..484190	+	2190	WP_168825848.1	EAL domain-containing protein	-
J8N69_RS02190 (J8N69_02190)	485092..485616	+	525	WP_168825850.1	hypothetical protein	Antitoxin
J8N69_RS02195 (J8N69_02195)	485618..486508	+	891	WP_168825852.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
J8N69_RS02200 (J8N69_02200)	486708..487154	-	447	Protein_433	transposase	-
J8N69_RS02205	487261..487587	-	327	WP_229426395.1	group II intron maturase-specific domain-containing protein	-
J8N69_RS02210 (J8N69_02205)	487562..488743	-	1182	WP_227803948.1	group II intron reverse transcriptase/maturase	-
J8N69_RS02215 (J8N69_02210)	489353..489877	-	525	Protein_436	IS5 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	489341..489799	458

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (36-265)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 297 a.a.
• Molecular weight: 34418.59 Da
• Isoelectric Point: 5.5097

>T199506 WP_168825852.1 NZ_CP073013:485618-486508 [Marinomonas profundi]
MLKEVIKQIVNTNPEYAGITPVIEKEILHHDIMAVMVKQGVMQSLTFIGGTSLRLCHNSSRLSEDLDFNGGYDFKPDDFD
GLEVEIQKYIQKKYETEVWVNKPNQDKQGDTSSWKISIEKEANRPDLPRQKMHIDICAIPSFDIERRPLINHYDVVVPTE
GLLIPVQSLEETLADKFIALAYRSRRIKPRDVWDILWIKQRGIDVSIELISKKLAAREKTKANFIESLTLQVEKLLNEEE
VKADFNNEMSRFIPSQIKQRTIDNPEYWQYVQLEIKSMTDPILRPDLQTKKFDMGL

Nucleotide

• Length: 891 bp

>T199506 NZ_CP097368:114000-114380 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin

Protein

• Length: 175 a.a.
• Molecular weight: 19399.52 Da
• Isoelectric Point: 9.9426

>AT199506 WP_168825850.1 NZ_CP073013:485092-485616 [Marinomonas profundi]
MRRKEKLLSVLSHTTKAGGGVHTATEIAFMLGEKHTPAFTKFLTDCVRQGVLRRVAAGIFESTITPPDGSTAIYKVVNKL
RGDVLNYISLESQLSYTGDISQIVMDRLTVMTKGRSGIFPTPYGVIEFTHTKKTIETIAPNIYFDSDIKMYRAKTTQALI
DLKNCNRNLHMLEA

Nucleotide

• Length: 525 bp

>AT199506 NZ_CP097368:113779-114000 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA