Detailed information of TA system TA199505

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 304789..305339
• Replicon: chromosome
• Accession: NZ_CP073013
• Organism: Marinomonas profundi strain M1K-6

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: J8N69_RS01350
• Protein ID: WP_168825096.1
• Coordinates: 305040..305339 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: J8N69_RS01345
• Protein ID: WP_168825098.1
• Coordinates: 304789..305031 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8N69_RS01325 (J8N69_01325)	300458..301456	-	999	WP_168825106.1	branched-chain amino acid aminotransferase	-
J8N69_RS01330 (J8N69_01330)	301748..302629	-	882	WP_168825104.1	diguanylate cyclase	-
J8N69_RS01335 (J8N69_01335)	302905..303663	+	759	WP_168825102.1	sulfite exporter TauE/SafE family protein	-
J8N69_RS01340 (J8N69_01340)	303698..304594	-	897	WP_211085000.1	EamA family transporter	-
J8N69_RS01345 (J8N69_01345)	304789..305031	+	243	WP_168825098.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
J8N69_RS01350 (J8N69_01350)	305040..305339	+	300	WP_168825096.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J8N69_RS01355 (J8N69_01355)	305478..306371	-	894	WP_168825094.1	DMT family transporter	-
J8N69_RS01360 (J8N69_01360)	306511..307332	+	822	WP_168825092.1	HAD-IIB family hydrolase	-
J8N69_RS01365 (J8N69_01365)	307385..308614	+	1230	WP_168825090.1	glycosyl transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-54)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11583.20 Da
• Isoelectric Point: 9.6601

>T199505 WP_168825096.1 NZ_CP073013:305040-305339 [Marinomonas profundi]
MHHNQYKLSNVAQAHLRKVKNYTINNFSEWQWQRYKETLLSGFQMLADNPALGQGCHEIYRNGFYFPIGKHTAYFTKEDG
FILIVAVLGQSQLPQNHLK

Nucleotide

• Length: 300 bp

>T199505 NZ_CP097368:c103627-103322 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9093.48 Da
• Isoelectric Point: 6.2161

>AT199505 WP_168825098.1 NZ_CP073013:304789-305031 [Marinomonas profundi]
MHTLTANDAKRNFGELLLNAQRQPIKISKNSKDAVVVMSIHDYEELEMMKAEYLKHCFIAAKDDLAKGNIVDGKDFLNEL

Nucleotide

• Length: 243 bp

>AT199505 NZ_CP097368:c103847-103629 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA