Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2272095..2272609 Replicon chromosome
Accession NZ_CP073012
Organism Staphylococcus aureus strain SA14+

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag KAJ74_RS11010 Protein ID WP_000581793.1
Coordinates 2272400..2272609 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KAJ74_RS11005 Protein ID WP_000138932.1
Coordinates 2272095..2272388 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KAJ74_RS10985 (KAJ74_10985) 2267557..2268198 + 642 WP_000483155.1 thiamine phosphate synthase -
KAJ74_RS10990 (KAJ74_10990) 2268284..2269156 + 873 WP_000725802.1 membrane protein insertase YidC -
KAJ74_RS10995 (KAJ74_10995) 2269770..2270417 - 648 WP_031590210.1 HD domain-containing protein -
KAJ74_RS11000 (KAJ74_11000) 2270445..2271929 - 1485 WP_000571549.1 cardiolipin synthase -
KAJ74_RS11005 (KAJ74_11005) 2272095..2272388 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KAJ74_RS11010 (KAJ74_11010) 2272400..2272609 + 210 WP_000581793.1 heavy metal-associated domain-containing protein Toxin
KAJ74_RS11015 (KAJ74_11015) 2272737..2272874 + 138 WP_000828354.1 Lmo0850 family protein -
KAJ74_RS11020 (KAJ74_11020) 2273137..2274339 - 1203 WP_031590208.1 FtsW/RodA/SpoVE family cell cycle protein -
KAJ74_RS11025 (KAJ74_11025) 2274657..2275727 + 1071 WP_000159627.1 D-alanine--D-alanine ligase -
KAJ74_RS11030 (KAJ74_11030) 2275742..2277100 + 1359 WP_000611482.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T199496 WP_000581793.1 NZ_CP073012:2272400-2272609 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T199496 NZ_CP097367:2756534-2756641 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT199496 WP_000138932.1 NZ_CP073012:2272095-2272388 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT199496 NZ_CP097367:c2756477-2756422 [Escherichia coli]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References