Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 695324..695801 | Replicon | chromosome |
| Accession | NZ_CP073012 | ||
| Organism | Staphylococcus aureus strain SA14+ | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | T1Y7S2 |
| Locus tag | KAJ74_RS03300 | Protein ID | WP_000052076.1 |
| Coordinates | 695613..695801 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | KAJ74_RS03295 | Protein ID | WP_001059690.1 |
| Coordinates | 695324..695584 (+) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KAJ74_RS03260 (KAJ74_03260) | 690716..691432 | - | 717 | WP_031589686.1 | type I 3-dehydroquinate dehydratase | - |
| KAJ74_RS03265 (KAJ74_03265) | 691580..692002 | + | 423 | WP_000974460.1 | organic hydroperoxide resistance protein | - |
| KAJ74_RS03270 (KAJ74_03270) | 692401..692895 | + | 495 | WP_000569884.1 | GNAT family N-acetyltransferase | - |
| KAJ74_RS03275 (KAJ74_03275) | 693051..693668 | + | 618 | WP_000255553.1 | LysE/ArgO family amino acid transporter | - |
| KAJ74_RS03280 (KAJ74_03280) | 693741..694322 | - | 582 | WP_001140697.1 | histidine phosphatase family protein | - |
| KAJ74_RS03285 (KAJ74_03285) | 694547..694783 | + | 237 | WP_000368687.1 | hypothetical protein | - |
| KAJ74_RS03290 (KAJ74_03290) | 694780..694983 | - | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| KAJ74_RS03295 (KAJ74_03295) | 695324..695584 | + | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| KAJ74_RS03300 (KAJ74_03300) | 695613..695801 | + | 189 | WP_000052076.1 | hypothetical protein | Toxin |
| KAJ74_RS03305 (KAJ74_03305) | 695989..696558 | + | 570 | WP_001106652.1 | lipoprotein N-acylation protein LnsA | - |
| KAJ74_RS03310 (KAJ74_03310) | 696646..696930 | + | 285 | WP_031590186.1 | hypothetical protein | - |
| KAJ74_RS03315 (KAJ74_03315) | 696992..697210 | + | 219 | WP_000005887.1 | hypothetical protein | - |
| KAJ74_RS03320 (KAJ74_03320) | 697706..697906 | - | 201 | WP_001059082.1 | cold-shock protein | - |
| KAJ74_RS03325 (KAJ74_03325) | 698263..698949 | - | 687 | WP_001641381.1 | thermonuclease family protein | - |
| KAJ74_RS03330 (KAJ74_03330) | 699290..699766 | - | 477 | WP_000824477.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T199487 WP_000052076.1 NZ_CP073012:695613-695801 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T199487 NZ_CP097367:643884-644198 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT199487 WP_001059690.1 NZ_CP073012:695324-695584 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT199487 NZ_CP097367:644195-644611 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VP18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |