Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 29973..30466 Replicon plasmid unnamed3
Accession NZ_CP073005
Organism Klebsiella pneumoniae strain FO15

Toxin (Protein)


Gene name TsxA Uniprot ID U9Y9W8
Locus tag KBT91_RS28075 Protein ID WP_001230709.1
Coordinates 30212..30466 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID U9Y4R8
Locus tag KBT91_RS28070 Protein ID WP_000151456.1
Coordinates 29973..30215 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KBT91_RS28040 25296..25589 - 294 WP_000954637.1 hypothetical protein -
KBT91_RS28045 25604..25978 - 375 WP_015387341.1 hypothetical protein -
KBT91_RS28050 26030..26317 - 288 WP_000673430.1 hypothetical protein -
KBT91_RS28055 27067..28329 + 1263 WP_000608644.1 IS1380-like element ISEcp1 family transposase -
KBT91_RS28060 28582..29457 + 876 WP_015387340.1 extended-spectrum class A beta-lactamase CTX-M-55 -
KBT91_RS28065 29504..29848 - 345 Protein_33 WbuC family cupin fold metalloprotein -
KBT91_RS28070 29973..30215 - 243 WP_000151456.1 hypothetical protein Antitoxin
KBT91_RS28075 30212..30466 - 255 WP_001230709.1 hypothetical protein Toxin
KBT91_RS28080 30463..31005 - 543 WP_001083904.1 hypothetical protein -
KBT91_RS28085 31109..31624 - 516 WP_001025393.1 J domain-containing protein -
KBT91_RS28090 32028..32357 - 330 WP_000855119.1 hypothetical protein -
KBT91_RS28095 32944..33609 + 666 WP_015387337.1 division plane positioning ATPase MipZ -
KBT91_RS28100 33683..33967 + 285 WP_001162371.1 hypothetical protein -
KBT91_RS28105 33985..34581 - 597 WP_000125165.1 ProQ/FINO family protein -
KBT91_RS28110 34730..34852 - 123 WP_223202818.1 Hok/Gef family protein -
KBT91_RS28115 34797..34949 - 153 Protein_43 DUF5431 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid blaCTX-M-55 - 1..62001 62001
- flank IS/Tn blaCTX-M-55 - 27067..29457 2390


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9942.47 Da        Isoelectric Point: 10.1206

>T199485 WP_001230709.1 NZ_CP073005:c30466-30212 [Klebsiella pneumoniae]
MRKNKGRLTYYLEVIDKKYHFVKKISSYSKEFTDGKTKRTKRTLSELVFNESEVEAIDFTKNGLRPVDKNILLTMVKEYK
ESDA

Download         Length: 255 bp

>T199485 NZ_CP097367:188541-188648 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGTTCCGGTCATTACTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9136.45 Da        Isoelectric Point: 7.2775

>AT199485 WP_000151456.1 NZ_CP073005:c30215-29973 [Klebsiella pneumoniae]
MTIENTPENIKKLRKKIGLTQTECGEIFGVGLSTWQKKEAKTHNQLNLSKGEFEYLLLLAGEHPEYVLHKKAESRSPEEP

Download         Length: 243 bp

>AT199485 NZ_CP097367:c188484-188427 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G9H8F0

Antitoxin

Source ID Structure
AlphaFold DB A0A3G9GNF5

References