199484

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 466..940 Replicon plasmid unnamed2
Accession NZ_CP073004
Organism Klebsiella pneumoniae strain FO15

Toxin (Protein)


Gene name pasB Uniprot ID A0A8J3DT22
Locus tag KBT91_RS27825 Protein ID WP_004197762.1
Coordinates 466..732 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID S1EJF5
Locus tag KBT91_RS27830 Protein ID WP_000879771.1
Coordinates 716..940 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KBT91_RS27820 46..396 + 351 WP_004197756.1 hypothetical protein -
KBT91_RS27825 466..732 - 267 WP_004197762.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KBT91_RS27830 716..940 - 225 WP_000879771.1 DUF6290 family protein Antitoxin
KBT91_RS27835 1607..1819 - 213 WP_021527181.1 MbeD family mobilization/exclusion protein -
KBT91_RS27840 1826..2335 - 510 WP_032433972.1 MbeB family mobilization protein -
KBT91_RS27845 2370..2804 - 435 Protein_5 relaxase/mobilization nuclease domain-containing protein -
KBT91_RS27850 3013..3357 - 345 WP_062955149.1 MobC family plasmid mobilization relaxosome protein -
KBT91_RS27855 3347..3523 - 177 WP_004197757.1 hypothetical protein -
KBT91_RS27860 4679..5005 + 327 WP_050516389.1 hypothetical protein -
KBT91_RS27865 5031..5576 + 546 WP_023317533.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..9417 9417


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-45)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10342.96 Da        Isoelectric Point: 9.8727

>T199484 WP_004197762.1 NZ_CP073004:c732-466 [Klebsiella pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp

>T199484 NZ_CP097367:188058-188165 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8369.28 Da        Isoelectric Point: 4.6533

>AT199484 WP_000879771.1 NZ_CP073004:c940-716 [Klebsiella pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD

Download         Length: 225 bp

>AT199484 NZ_CP097367:c188009-187944 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1EJF5

References