Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4890406..4890922 Replicon chromosome
Accession NZ_CP073002
Organism Klebsiella pneumoniae strain FO15

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag KBT91_RS24155 Protein ID WP_002886902.1
Coordinates 4890406..4890690 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KBT91_RS24160 Protein ID WP_002886901.1
Coordinates 4890680..4890922 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KBT91_RS24130 4885890..4886153 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
KBT91_RS24135 4886283..4886456 + 174 WP_002886906.1 hypothetical protein -
KBT91_RS24140 4886459..4887202 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KBT91_RS24145 4887559..4889697 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
KBT91_RS24150 4889938..4890402 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KBT91_RS24155 4890406..4890690 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KBT91_RS24160 4890680..4890922 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KBT91_RS24165 4891000..4892910 - 1911 WP_004152270.1 PRD domain-containing protein -
KBT91_RS24170 4892933..4894087 - 1155 WP_002886900.1 lactonase family protein -
KBT91_RS24175 4894153..4894893 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T199474 WP_002886902.1 NZ_CP073002:c4890690-4890406 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T199474 NZ_CP097360:2950545-2950823 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT199474 WP_002886901.1 NZ_CP073002:c4890922-4890680 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT199474 NZ_CP097360:2950352-2950543 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGTAAGGAACGGAGCAAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References