Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 875495..876149 Replicon chromosome
Accession NZ_CP073002
Organism Klebsiella pneumoniae strain FO15

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag KBT91_RS04420 Protein ID WP_004144731.1
Coordinates 875742..876149 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KBT91_RS04415 Protein ID WP_002916312.1
Coordinates 875495..875761 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KBT91_RS04390 870651..872084 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
KBT91_RS04395 872203..872931 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KBT91_RS04400 872981..873292 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
KBT91_RS04405 873456..874115 + 660 WP_002916317.1 hemolysin III family protein -
KBT91_RS04410 874266..875249 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
KBT91_RS04415 875495..875761 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KBT91_RS04420 875742..876149 + 408 WP_004144731.1 protein YgfX Toxin
KBT91_RS04425 876156..876677 - 522 WP_002916308.1 flavodoxin FldB -
KBT91_RS04430 876778..877674 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KBT91_RS04435 877697..878410 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KBT91_RS04440 878416..880149 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T199462 WP_004144731.1 NZ_CP073002:875742-876149 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T199462 NZ_CP097360:188541-188648 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGTTCCGGTCATTACTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT199462 WP_002916312.1 NZ_CP073002:875495-875761 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT199462 NZ_CP097360:c188484-188427 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References