Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 21126..21796 | Replicon | plasmid p1878-217k |
| Accession | NZ_CP072997 | ||
| Organism | Klebsiella pneumoniae strain KP1878 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | Q6U619 |
| Locus tag | KA532_RS26865 | Protein ID | WP_004213072.1 |
| Coordinates | 21353..21796 (+) | Length | 148 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | Q6U620 |
| Locus tag | KA532_RS26860 | Protein ID | WP_004213073.1 |
| Coordinates | 21126..21356 (+) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KA532_RS26835 (KA532_26835) | 16311..17090 | - | 780 | WP_004213560.1 | site-specific integrase | - |
| KA532_RS26840 (KA532_26840) | 17087..17908 | - | 822 | WP_004213562.1 | hypothetical protein | - |
| KA532_RS26845 (KA532_26845) | 18880..19086 | + | 207 | WP_004213077.1 | hypothetical protein | - |
| KA532_RS26850 (KA532_26850) | 19076..19369 | - | 294 | WP_004213076.1 | hypothetical protein | - |
| KA532_RS26855 (KA532_26855) | 19385..20518 | - | 1134 | WP_004213075.1 | DUF3800 domain-containing protein | - |
| KA532_RS26860 (KA532_26860) | 21126..21356 | + | 231 | WP_004213073.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| KA532_RS26865 (KA532_26865) | 21353..21796 | + | 444 | WP_004213072.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| KA532_RS29365 | 21945..22196 | + | 252 | WP_186987481.1 | hypothetical protein | - |
| KA532_RS26875 (KA532_26875) | 22219..22523 | - | 305 | Protein_27 | transposase | - |
| KA532_RS26880 (KA532_26880) | 22941..23579 | + | 639 | WP_032488580.1 | mucoid phenotype regulator RmpA2 | - |
| KA532_RS26885 (KA532_26885) | 24097..24500 | - | 404 | Protein_29 | GAF domain-containing protein | - |
| KA532_RS26890 (KA532_26890) | 24591..25511 | - | 921 | WP_004213934.1 | DUF1471 domain-containing protein | - |
| KA532_RS26895 (KA532_26895) | 25560..26051 | - | 492 | WP_011251327.1 | DM13 domain-containing protein | - |
| KA532_RS26900 (KA532_26900) | 26114..26389 | - | 276 | WP_004213932.1 | carboxymuconolactone decarboxylase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | - | rmpA / iutA / iucD / iucC / iucB / iucA / rmpA | 1..217255 | 217255 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 148 a.a. Molecular weight: 16006.74 Da Isoelectric Point: 9.3642
>T199451 WP_004213072.1 NZ_CP072997:21353-21796 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVKKAALCRVIS
Download Length: 444 bp
>T199451 NZ_CP097346:c83477-82992 [Enterobacter hormaechei subsp. xiangfangensis]
GTGGGACGTGTAACAGCACCAGAACCGTTAACAAGCTCCCATCAACTTACTGAGTTCGTCAGTGGCGAGGCTGTACTAGA
TGACTGGCTTAAACAGAGAGGATTAAAAAATCAGGCTCTCGGTTCAGCCCGAACGTTTGTTGTTTGTAAAACAGGCACGA
AACAGGTTGTCGGTTTTTACTCTCTGGCCACCGGCAGCGTTAACCACGTAGAAGCAACGGGAAATATCAGGCGCAATATG
CCAGATCCAATTCCCGTAATCATACTTGCTCGCCTGGCAGTCGATGTTTCATTCCGTGGAAAAGGGCTCGGAGCTGATTT
ACTGCATGATGCAGTTCTGCGTTGTTACCGTGTAGCTGAAAATATTGGAGTCCGTGCCATTATGGTTCATGCACTGACTG
AAGTGGCCAAAAGCTTTTATCTTCATCATGGTTTTAAGGCATCACAAACCCAGGAGCGGACTTTGTTTCTCAAACTACCA
CAGTAG
GTGGGACGTGTAACAGCACCAGAACCGTTAACAAGCTCCCATCAACTTACTGAGTTCGTCAGTGGCGAGGCTGTACTAGA
TGACTGGCTTAAACAGAGAGGATTAAAAAATCAGGCTCTCGGTTCAGCCCGAACGTTTGTTGTTTGTAAAACAGGCACGA
AACAGGTTGTCGGTTTTTACTCTCTGGCCACCGGCAGCGTTAACCACGTAGAAGCAACGGGAAATATCAGGCGCAATATG
CCAGATCCAATTCCCGTAATCATACTTGCTCGCCTGGCAGTCGATGTTTCATTCCGTGGAAAAGGGCTCGGAGCTGATTT
ACTGCATGATGCAGTTCTGCGTTGTTACCGTGTAGCTGAAAATATTGGAGTCCGTGCCATTATGGTTCATGCACTGACTG
AAGTGGCCAAAAGCTTTTATCTTCATCATGGTTTTAAGGCATCACAAACCCAGGAGCGGACTTTGTTTCTCAAACTACCA
CAGTAG
Antitoxin
Download Length: 77 a.a. Molecular weight: 8677.73 Da Isoelectric Point: 4.4563
>AT199451 WP_004213073.1 NZ_CP072997:21126-21356 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP
Download Length: 231 bp
>AT199451 NZ_CP097346:c83731-83465 [Enterobacter hormaechei subsp. xiangfangensis]
ATGAAATCCGATATTCAGCTCAATCTTAGAGCCAAGGAATCGCAAAGAGCACTCATCGATGCTGCTGCAGAGATTCTCCA
TAAATCACGTACAGACTTCATTCTGGAAATGGCATGCCAGGCTGCGGAGAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAGCAGTATGCAGAATTTATCGATATGCTCGATGCACCAGTTTCGGATGATGCTGCCATTGATAAACTTCTG
GCAAGGAAACCTCAGTGGGACGTGTAA
ATGAAATCCGATATTCAGCTCAATCTTAGAGCCAAGGAATCGCAAAGAGCACTCATCGATGCTGCTGCAGAGATTCTCCA
TAAATCACGTACAGACTTCATTCTGGAAATGGCATGCCAGGCTGCGGAGAATGTGATCCTCGATCGGCGTGTATTCAATT
TTAACGATGAGCAGTATGCAGAATTTATCGATATGCTCGATGCACCAGTTTCGGATGATGCTGCCATTGATAAACTTCTG
GCAAGGAAACCTCAGTGGGACGTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|