199427

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 3354515..3354900 Replicon chromosome
Accession NZ_CP072988
Organism Xanthomonas translucens pv. translucens strain CIX43

Toxin (Protein)


Gene name EcnB Uniprot ID A0A0K2ZHE5
Locus tag KBQ49_RS14695 Protein ID WP_003469322.1
Coordinates 3354515..3354649 (-) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID A0A1C3TTT1
Locus tag KBQ49_RS14700 Protein ID WP_003469323.1
Coordinates 3354748..3354900 (-) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KBQ49_RS14680 (KBQ49_14615) 3350951..3351874 - 924 WP_003476575.1 MBL fold metallo-hydrolase -
KBQ49_RS14685 (KBQ49_14620) 3351944..3353344 - 1401 WP_003476576.1 tryptophan--tRNA ligase -
KBQ49_RS14690 (KBQ49_14625) 3353455..3354306 + 852 WP_003476578.1 hypothetical protein -
KBQ49_RS14695 (KBQ49_14630) 3354515..3354649 - 135 WP_003469322.1 entericidin A/B family lipoprotein Toxin
KBQ49_RS14700 (KBQ49_14635) 3354748..3354900 - 153 WP_003469323.1 entericidin A/B family lipoprotein Antitoxin
KBQ49_RS14705 (KBQ49_14640) 3355044..3355967 - 924 WP_058360588.1 arginase -
KBQ49_RS14715 (KBQ49_14650) 3356355..3357191 - 837 WP_161993387.1 SPOR domain-containing protein -
KBQ49_RS14720 (KBQ49_14655) 3357201..3357941 - 741 WP_004427869.1 type III pantothenate kinase -
KBQ49_RS14725 (KBQ49_14660) 3357938..3358933 - 996 WP_153476936.1 bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA -
KBQ49_RS14730 (KBQ49_14665) 3359071..3359343 + 273 WP_003476582.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-39)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4604.40 Da        Isoelectric Point: 9.2977

>T199427 WP_003469322.1 NZ_CP072988:c3354649-3354515 [Xanthomonas translucens pv. translucens]
MKRTFAWMLLAMFSVGLLSGCNTVAGAGKDVKSAGEKVEDAAKN

Download         Length: 135 bp

>T199427 NZ_CP097339:c1505918-1505622 [Mannheimia haemolytica]
ATGTATATAGATTTGCAATATGCTGTGCCGTTATTGTTTGAATACGACCCGAACAAAAGCCAAATTAATTTAGCCAAATA
TGGTATTGATTTTGAACAGGCAAAGTTGCTTTGGGAAGATGAACGAAAAGTTGTACTGGAGGCTTGCATTGAACCCGAAT
TACGCTATTTCCTGATTGGCAAGATTTATGATAAATATTGGACAGCGTTTTTTACACCAAGAAATGATGTTATTCGTTTA
ATTTCAGTTAGACGTTCCCGTAAAAAAGAGATCTCATACTATGAGAAATACCATTAG

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5350.35 Da        Isoelectric Point: 8.1210

>AT199427 WP_003469323.1 NZ_CP072988:c3354900-3354748 [Xanthomonas translucens pv. translucens]
MKRLFTLTMLTLFCAGMLTGCNTMAGAGKDMQKAGDKVETKADDCKDGKC

Download         Length: 153 bp

>AT199427 NZ_CP097339:c1505638-1505396 [Mannheimia haemolytica]
ATGAGAAATACCATTAGTGCCGAAGAATTAGAACGTATCTTCGATGAAGGCAAAGAAGATATTTTACAATACTGCGATCT
TTCTACCGCTCATCGCCCGGGGCAAATGAAAAGGGTGAATGTTGATTTCCCAAATTGGATGGTAGAAGCGTTAGATAAGC
AAGCCAGACATTTAGGTGTGCCTCGCCAAGCCTTGATTAAAATGTGGATTGCGGAAAAATTACCGGTTCAATCACCTAGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K2ZHE5

Antitoxin

Source ID Structure
AlphaFold DB A0A1C3TTT1

References