Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 2187818..2189507 Replicon chromosome
Accession NZ_CP072980
Organism Escherichia coli strain 2547

Toxin (Protein)


Gene name mosT Uniprot ID A0A061KTE0
Locus tag KBW66_RS10550 Protein ID WP_000365807.1
Coordinates 2188587..2189507 (+) Length 307 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag KBW66_RS10545 Protein ID WP_001295795.1
Coordinates 2187818..2188600 (+) Length 261 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KBW66_RS10540 (2184436) 2184436..2187534 - 3099 WP_000673070.1 type I restriction endonuclease -
KBW66_RS10545 (2187818) 2187818..2188600 + 783 WP_001295795.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
KBW66_RS10550 (2188587) 2188587..2189507 + 921 WP_000365807.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
KBW66_RS26650 (2189672) 2189672..2190448 - 777 WP_000171155.1 site-specific integrase -
KBW66_RS26655 (2190656) 2190656..2190991 - 336 WP_000996167.1 Arm DNA-binding domain-containing protein -
KBW66_RS10560 (2191218) 2191218..2191376 - 159 Protein_2077 integrase -
KBW66_RS10565 (2191425) 2191425..2191610 + 186 WP_000146240.1 hypothetical protein -
KBW66_RS10570 (2191825) 2191825..2192439 + 615 WP_001019923.1 YagU family protein -
KBW66_RS10575 (2192510) 2192510..2192676 + 167 Protein_2080 tail fiber assembly protein -
KBW66_RS10580 (2192688) 2192688..2193017 - 330 WP_001295797.1 YkgJ family cysteine cluster protein -
KBW66_RS10585 (2193324) 2193324..2194034 - 711 WP_001295798.1 fimbrial chaperone EcpE -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 307 a.a.        Molecular weight: 34570.89 Da        Isoelectric Point: 7.3239

>T199368 WP_000365807.1 NZ_CP072980:2188587-2189507 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Download         Length: 921 bp

>T199368 NZ_CP097329:c4384570-4384151 [Pseudanabaena mucicola str. Chao 1806]
ATGCAAGGTAATCCACTTCGCCTTGTTATCGACACGAATATTTGGATTAGCTTTCTCATTGGCAAATCACTTACGGGTCT
GAGCGAAGCGATCATTAGCGATCAAGTAATCGTTCTATTTAGCAATGACCTATTTGGCGAATTAATTAAAGTTTTGAAAC
GTCCAAAATTTAAAAAATACTTTTCAGAAACCGCCATTGAAGATTTAGTGACACTTCTCTATGAAAAAGTTGAATTGATC
GAAATTACTCACCATTTTGAAGATTGTCGTGATGCAAAAGATAATTTTCTCTTGGATTTAGCCGTATCAGGTCATGCAAA
TTACCTAGTCACAGGTGATGCAGATTTGTTGATATTAAACCCTTTTCAAGGTGTAGAAATTATTTCGTATCAACATTTTC
AGAATCTGATTTTAAAATAA

Antitoxin


Download         Length: 261 a.a.        Molecular weight: 29099.24 Da        Isoelectric Point: 8.5975

>AT199368 WP_001295795.1 NZ_CP072980:2187818-2188600 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Download         Length: 783 bp

>AT199368 NZ_CP097329:c4384778-4384560 [Pseudanabaena mucicola str. Chao 1806]
ATGAATGTATCCATCTCCATAGATTTCTCTCAACTTAAAACAGCGATCGCACAATGCAATCTAGAAGAAAAGCTGGAATT
ATTGCAGTTGCTAGAAAAAGACACATTTTCAGTGAGATTCAATAAATTTTTAAGTTCAGTACAAACTGACGAACTAAGTT
TAGAAGATATTACCCAAGAAGTTGAAGCCGTAAGGCAAGCAAATTATCATGCAAGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A061KTE0


Antitoxin

Source ID Structure

References