Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 270323..270849 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP072971 | ||
| Organism | Enterobacter sp. BWH 37 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | IBG18_RS24765 | Protein ID | WP_000323025.1 |
| Coordinates | 270323..270610 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | IBG18_RS24770 | Protein ID | WP_000534858.1 |
| Coordinates | 270610..270849 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IBG18_RS24730 | 265893..266069 | - | 177 | WP_001371930.1 | hypothetical protein | - |
| IBG18_RS24735 | 266580..267524 | + | 945 | WP_000778029.1 | DUF5417 domain-containing protein | - |
| IBG18_RS24740 | 267620..268222 | + | 603 | WP_012695474.1 | hypothetical protein | - |
| IBG18_RS24745 | 268282..268632 | + | 351 | WP_000743059.1 | hypothetical protein | - |
| IBG18_RS24750 | 268679..268882 | + | 204 | WP_001015183.1 | hypothetical protein | - |
| IBG18_RS24755 | 269164..269484 | + | 321 | WP_000332796.1 | hypothetical protein | - |
| IBG18_RS24760 | 270097..270222 | - | 126 | WP_229020258.1 | DUF5431 family protein | - |
| IBG18_RS24765 | 270323..270610 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| IBG18_RS24770 | 270610..270849 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| IBG18_RS26060 | 270874..270978 | + | 105 | Protein_277 | hypothetical protein | - |
| IBG18_RS24775 | 271112..272035 | - | 924 | WP_000167917.1 | cation diffusion facilitator family transporter | - |
| IBG18_RS24780 | 272235..272807 | - | 573 | WP_001515348.1 | cytochrome b/b6 domain-containing protein | - |
| IBG18_RS24785 | 273283..274521 | - | 1239 | WP_000219087.1 | IS110-like element ISEsa2 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | sul1 / qacE / ant(3'')-Ia / blaOXA-129 / dfrA21 / aph(6)-Id / aph(3'')-Ib / tet(B) / formA / mcr-9 / blaKPC-4 | - | 1..342015 | 342015 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T199326 WP_000323025.1 NZ_CP072971:c270610-270323 [Enterobacter sp. BWH 37]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T199326 NZ_CP097320:1839874-1840155 [Candidatus Mycobacterium methanotrophicum]
GTGATCCGCTCCTTCCGGGCCAAGGACACCGAGGCGATCTGGCAGCGCCGCTACGTCAAGGAGCTCAGCCCGGAGCTCAG
CAGGCTCACCTACAACAAGCTCGTTCTCATCAATGCCGCGGAGAGCATCAACGATCTTCGTGTGCCACCGGGCAACCGGC
CGGAGAAGCCGAGCGGCATCCGCGCCGGCCAATACAGCGTCCGCGTAAACGACCAGTGGCGGCTGTGCTTCACCTGGAGC
ACAGCCGGCGCTGGCGACGTGGAGCTGGTCGACTATCACTAG
GTGATCCGCTCCTTCCGGGCCAAGGACACCGAGGCGATCTGGCAGCGCCGCTACGTCAAGGAGCTCAGCCCGGAGCTCAG
CAGGCTCACCTACAACAAGCTCGTTCTCATCAATGCCGCGGAGAGCATCAACGATCTTCGTGTGCCACCGGGCAACCGGC
CGGAGAAGCCGAGCGGCATCCGCGCCGGCCAATACAGCGTCCGCGTAAACGACCAGTGGCGGCTGTGCTTCACCTGGAGC
ACAGCCGGCGCTGGCGACGTGGAGCTGGTCGACTATCACTAG
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT199326 WP_000534858.1 NZ_CP072971:c270849-270610 [Enterobacter sp. BWH 37]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT199326 NZ_CP097320:1840187-1840474 [Candidatus Mycobacterium methanotrophicum]
ATGGCAGATTTCGCACCCACCCACCCCGGCGAGATTCTCTTGACCGAATTTCTCGCGCCGATGGGGATCTCTCAATACCG
CGTTGCCAAGGTGATTGATGTGCCGCCGCGACGTATCAATGAGATCGTCCACGGCAAGCGGGGCATTAGCGCCGACACCG
CGCTTCGGCTATCGCGAGCGCTTGGCTTGACCGACATGTTCTTCATTAACATGCAGGCCCATTACGACGCCGAGATCGCA
CGTGAGCAGCTGGCGAACACGTTGGCAAGTATCGACCGCATCGCGTAA
ATGGCAGATTTCGCACCCACCCACCCCGGCGAGATTCTCTTGACCGAATTTCTCGCGCCGATGGGGATCTCTCAATACCG
CGTTGCCAAGGTGATTGATGTGCCGCCGCGACGTATCAATGAGATCGTCCACGGCAAGCGGGGCATTAGCGCCGACACCG
CGCTTCGGCTATCGCGAGCGCTTGGCTTGACCGACATGTTCTTCATTAACATGCAGGCCCATTACGACGCCGAGATCGCA
CGTGAGCAGCTGGCGAACACGTTGGCAAGTATCGACCGCATCGCGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|