Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 130470..132093 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP072971 | ||
| Organism | Enterobacter sp. BWH 37 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | C1IUI3 |
| Locus tag | IBG18_RS24065 | Protein ID | WP_000088044.1 |
| Coordinates | 130768..132093 (+) | Length | 442 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A6M3PBR7 |
| Locus tag | IBG18_RS24060 | Protein ID | WP_012477377.1 |
| Coordinates | 130470..130763 (+) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IBG18_RS24035 | 125499..125834 | - | 336 | Protein_128 | IS4 family transposase | - |
| IBG18_RS24045 | 127171..128058 | - | 888 | Protein_130 | IS4-like element ISVsa5 family transposase | - |
| IBG18_RS24050 | 128179..128676 | + | 498 | WP_000340139.1 | membrane protein | - |
| IBG18_RS24055 | 128681..130069 | + | 1389 | WP_000083579.1 | hypothetical protein | - |
| IBG18_RS24060 | 130470..130763 | + | 294 | WP_012477377.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| IBG18_RS24065 | 130768..132093 | + | 1326 | WP_000088044.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| IBG18_RS24070 | 132154..132360 | + | 207 | WP_000134171.1 | hypothetical protein | - |
| IBG18_RS24075 | 132461..132871 | + | 411 | WP_000985909.1 | hypothetical protein | - |
| IBG18_RS24080 | 132884..133699 | + | 816 | WP_001641519.1 | HNH endonuclease signature motif containing protein | - |
| IBG18_RS24085 | 133952..134398 | + | 447 | WP_223831793.1 | hypothetical protein | - |
| IBG18_RS24090 | 134437..135417 | - | 981 | WP_000019450.1 | IS5-like element ISKpn26 family transposase | - |
| IBG18_RS24095 | 135463..136086 | - | 624 | WP_000490639.1 | hypothetical protein | - |
| IBG18_RS24100 | 136144..136524 | - | 381 | WP_001371925.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | sul1 / qacE / ant(3'')-Ia / blaOXA-129 / dfrA21 / aph(6)-Id / aph(3'')-Ib / tet(B) / formA / mcr-9 / blaKPC-4 | - | 1..342015 | 342015 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 442 a.a. Molecular weight: 50333.32 Da Isoelectric Point: 6.5044
>T199325 WP_000088044.1 NZ_CP072971:130768-132093 [Enterobacter sp. BWH 37]
MSRKQQRLAIWMNGIKVGYWEKSKGVDSLQYLPDWSADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMRSSVENEWLCSVLLEQYGLPVARTQIAHFEDQKALVVERF
DRKWSGNGQWIIRLPQEDMCQALGISPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIVFWMMAATDGHAKNFS
ISIGPQGRYHLTPLYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
MSRKQQRLAIWMNGIKVGYWEKSKGVDSLQYLPDWSADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMRSSVENEWLCSVLLEQYGLPVARTQIAHFEDQKALVVERF
DRKWSGNGQWIIRLPQEDMCQALGISPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIVFWMMAATDGHAKNFS
ISIGPQGRYHLTPLYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
Download Length: 1326 bp
>T199325 NZ_CP097320:1665120-1665548 [Candidatus Mycobacterium methanotrophicum]
ATGAGGTTGCTGGACCTGAACATCCTCATCTACGCGATGGATGAGTCGTCGTCGCGTCACCAACGGGCGCGGGACTGGCT
CGACGACACCCTGTCCGGTTCGGACACCGTCGCTTTCGCTTGGCAGGTACTCGTCGGTTTTGTGCGGCTAGCTACGCGCG
CTGCAGTGTTTGCCCGGCCCCTCACGGTCGACGAGTCGTTCGACGTCGTCGACGGCTGGTTGGCGCAACCGTGCGTGACC
GTCGTGCACCCAACCGATCGCCATGCGAATGTGCTCCGGGGGCTGCTTATTCCTCTTGGCGCAGCGGGAAATCTAACCAG
CGATGCGCATCTTGCCGCCCTGGCCATCGAGCATGGCGCAGAATTGTGTTCCACCGACGTCGACTTCAGTCGATTTTCCG
GCGTCCGATGGATCGATCCGCTCGGGTAG
ATGAGGTTGCTGGACCTGAACATCCTCATCTACGCGATGGATGAGTCGTCGTCGCGTCACCAACGGGCGCGGGACTGGCT
CGACGACACCCTGTCCGGTTCGGACACCGTCGCTTTCGCTTGGCAGGTACTCGTCGGTTTTGTGCGGCTAGCTACGCGCG
CTGCAGTGTTTGCCCGGCCCCTCACGGTCGACGAGTCGTTCGACGTCGTCGACGGCTGGTTGGCGCAACCGTGCGTGACC
GTCGTGCACCCAACCGATCGCCATGCGAATGTGCTCCGGGGGCTGCTTATTCCTCTTGGCGCAGCGGGAAATCTAACCAG
CGATGCGCATCTTGCCGCCCTGGCCATCGAGCATGGCGCAGAATTGTGTTCCACCGACGTCGACTTCAGTCGATTTTCCG
GCGTCCGATGGATCGATCCGCTCGGGTAG
Antitoxin
Download Length: 98 a.a. Molecular weight: 10860.30 Da Isoelectric Point: 10.3134
>AT199325 WP_012477377.1 NZ_CP072971:130470-130763 [Enterobacter sp. BWH 37]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSTTASSEGK
QTEEMLKSNSPARQEKW
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSTTASSEGK
QTEEMLKSNSPARQEKW
Download Length: 294 bp
>AT199325 NZ_CP097320:1664866-1665123 [Candidatus Mycobacterium methanotrophicum]
ATGCGGACCACGGTGACGCTCGATCCCGATGTGGTTGCCGCGCTGCAGCGGGTGGCACGCCAGCGGGGGACGTCTTTCAA
GGCGGTGCTCAACGACGCGGTACGACGCGGGCTGGGCAGTGAACCAACCCGACGGCGTTATCGCACGCCGAGTCGTGACA
TGGGGATACGGCCAGAATTCGACGTCGATAAGGCAGTGGCCTTGGCCGCAGCCGACGAAGACGCGGAGATCGTGCGCAAA
CTCGCGCATCGCAAATGA
ATGCGGACCACGGTGACGCTCGATCCCGATGTGGTTGCCGCGCTGCAGCGGGTGGCACGCCAGCGGGGGACGTCTTTCAA
GGCGGTGCTCAACGACGCGGTACGACGCGGGCTGGGCAGTGAACCAACCCGACGGCGTTATCGCACGCCGAGTCGTGACA
TGGGGATACGGCCAGAATTCGACGTCGATAAGGCAGTGGCCTTGGCCGCAGCCGACGAAGACGCGGAGATCGTGCGCAAA
CTCGCGCATCGCAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2S1XXW1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6M3PBR7 |