Detailed information of TA system TA199324

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4585585..4586192
• Replicon: chromosome
• Accession: NZ_CP072970
• Organism: Enterobacter sp. BWH 37

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A4Q4AAS0
• Locus tag: IBG18_RS22450
• Protein ID: WP_057979982.1
• Coordinates: 4586007..4586192 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: IBG18_RS22445
• Protein ID: WP_023315016.1
• Coordinates: 4585585..4585992 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-129)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6852.08 Da
• Isoelectric Point: 11.5191

>T199324 WP_057979982.1 NZ_CP072970:c4586192-4586007 [Enterobacter sp. BWH 37]
VKSADIITVLVSHGWKCVRTKGSHHQFRHPVQKGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Nucleotide

• Length: 186 bp

>T199324 NZ_CP097320:c1256688-1256422 [Candidatus Mycobacterium methanotrophicum]
GTGAGTTGGACAGTGGGCCTTGCCAGCAGTGCGCGCCGCGACATCGACAAGCTGCCGCCGAGGGTAATACCCGCTGTGGT
GGAGTTCATCTATGGCCCTCTTGCTAGTGATCCGCGCCGCATCGGCAAGCCGCTGCGCGAAAATTTTCACGGACACTGGT
CTGCGCGCCGCGGCGACTACCGTGTGCTGTACATGCTTGATGAGCACCGTCAGCAGATCGTGATCATTAGAGTCGGCCAC
CGCTCCCAAGTCTACAGGCCCGGATGA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 15205.20 Da
• Isoelectric Point: 4.5036

>AT199324 WP_023315016.1 NZ_CP072970:c4585992-4585585 [Enterobacter sp. BWH 37]
MFYPAYIHSDSDGSASGFFPDVPGCFFAGDSLDDAFQDARDALTAHFEALFEMDEMLPLPGMVEAHLASHPEDFIGGQWL
LVDINMKQFEGRVERINITIPRRLLVKIDSFVSEHPQFTNRSAFLAEAARRVLPR

Nucleotide

• Length: 408 bp

>AT199324 NZ_CP097320:c1256960-1256685 [Candidatus Mycobacterium methanotrophicum]
ATGACTACCTTGCCGCTGACCGAAGCAAAGGCGAAGTTGAACGAGTTGATCGACAGTGCCATCAACACCCACGAACGCGT
GACCATTACCAGGCACGGCAAGCCCGCGGCGGTACTGATGTCTGTTGAGGATCTAGAGGCTCTTGAAGAGACGCTCTACT
GGCAGTCGCAGCCCGGCGTACATGAGGACATCGCGAAGGCGCGCGAGCAAGCCGAGGCGGGTTTGCTGATGACCGAGGGC
GAGGTCCGGCGCCGTTATGGCGTTGGCCACCGGTGA

Structures

Toxin

• AlphaFold DB: A0A4Q4AAS0