Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4114742..4115421 Replicon chromosome
Accession NZ_CP072970
Organism Enterobacter sp. BWH 37

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag IBG18_RS20135 Protein ID WP_032608412.1
Coordinates 4114742..4115083 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag IBG18_RS20140 Protein ID WP_020456353.1
Coordinates 4115104..4115421 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IBG18_RS20100 4110235..4110486 + 252 WP_032608418.1 hypothetical protein -
IBG18_RS20105 4110559..4110783 + 225 WP_032608417.1 colicin E3-like toxin immunity protein -
IBG18_RS20110 4110842..4111090 + 249 WP_032608415.1 bacteriocin immunity protein -
IBG18_RS20115 4111205..4111576 + 372 WP_032608414.1 hypothetical protein -
IBG18_RS20120 4111656..4112129 - 474 WP_072163380.1 SymE family type I addiction module toxin -
IBG18_RS20125 4112430..4113299 + 870 WP_032608413.1 HNH endonuclease -
IBG18_RS20130 4113480..4114487 - 1008 WP_020456355.1 restriction endonuclease -
IBG18_RS20135 4114742..4115083 - 342 WP_032608412.1 TA system toxin CbtA family protein Toxin
IBG18_RS20140 4115104..4115421 - 318 WP_020456353.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IBG18_RS20145 4115439..4115660 - 222 WP_032608411.1 DUF987 domain-containing protein -
IBG18_RS20150 4115669..4116148 - 480 WP_020456351.1 DNA repair protein RadC -
IBG18_RS20155 4116191..4116409 - 219 WP_020456350.1 hypothetical protein -
IBG18_RS20160 4116419..4116877 - 459 WP_032608410.1 antirestriction protein -
IBG18_RS20165 4116983..4117183 - 201 WP_050596949.1 DUF905 family protein -
IBG18_RS20170 4117311..4118177 - 867 WP_032608409.1 hypothetical protein -
IBG18_RS26115 4118241..4118363 - 123 WP_020456347.1 hypothetical protein -
IBG18_RS20175 4118416..4119099 - 684 WP_020456346.1 DeoR family transcriptional regulator -
IBG18_RS20180 4119308..4120132 - 825 Protein_3965 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island fosA - 4105337..4148768 43431


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12747.73 Da        Isoelectric Point: 9.0060

>T199323 WP_032608412.1 NZ_CP072970:c4115083-4114742 [Enterobacter sp. BWH 37]
MKTLPATTPQAVTLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLKRNRISAAR

Download         Length: 342 bp

>T199323 NZ_CP097320:c1250166-1249774 [Candidatus Mycobacterium methanotrophicum]
ATGACGGCTCGGCGAGCGGTGGTCGATACGTCTGTTCTGATCGGCCTTGAATCGGCGCGAGTCGACGCCGCCCGGTTTGC
GGAGTATGAATTCGGTGTCTCGGTGATCACGCTGGGTGAGCTGCGGCTCGGAGTGCTGCAGGCCTCCGGTCCTGAGGCGA
GTGCGCGTCGACTGTCGACCTATCAGCTCGCCCAGCGGTTCGAACCGCTTACCATCGATGAGGCCGTTTCCGAAGCCTGG
GCACTGCTGGTCTCCCGGCTCCGAGCAGCGAATCGGCGTGTGCCGATTAATGATAGCTGGATCGCAGCGACCGCCATGGC
CCACAACCTTCCTATCCTGACGCAGGATAGCGATTACGACGCAATGACAGATGTCGCGGTCATCAAGCTCTAG

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11846.39 Da        Isoelectric Point: 5.5403

>AT199323 WP_020456353.1 NZ_CP072970:c4115421-4115104 [Enterobacter sp. BWH 37]
MSNTTWGLQRDITPRLGARLVQEGNWLHYLADRASITGKFSEAECLKLDVVFPNFISQLESMLTTGEMNPSHAYCVTLYH
NGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 318 bp

>AT199323 NZ_CP097320:c1250417-1250163 [Candidatus Mycobacterium methanotrophicum]
ATGGCTGCTATTCCGGCGCGCGACCTCCGCAATCACACCGCCCAGGTTTTGCGGCGGGTTGAGGCCGGCGAGGAGATCGA
GGTGTTCAAAGACAATCGCCCGGTGGCGAAGCTCGTTCCGTTGCCGCGGCGCCGTCAGTGGTTGCCGGCATCCGAGGTGA
TCGGCGAACTATCGCGTCTCGGCCCTGACACCACAGGACTTAATGCGGAACTTGGAGAAGCGCTGACGGACACGACGGAT
GATGTGTCGTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References