Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3594900..3595520 Replicon chromosome
Accession NZ_CP072970
Organism Enterobacter sp. BWH 37

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag IBG18_RS17720 Protein ID WP_015571250.1
Coordinates 3595302..3595520 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag IBG18_RS17715 Protein ID WP_006809850.1
Coordinates 3594900..3595274 (+) Length 125 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IBG18_RS17705 3590027..3591220 + 1194 WP_022650498.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IBG18_RS17710 3591243..3594389 + 3147 WP_022650497.1 multidrug efflux RND transporter permease subunit AcrB -
IBG18_RS17715 3594900..3595274 + 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
IBG18_RS17720 3595302..3595520 + 219 WP_015571250.1 HHA domain-containing protein Toxin
IBG18_RS17725 3595729..3596280 + 552 WP_022650496.1 maltose O-acetyltransferase -
IBG18_RS17730 3596397..3596864 + 468 WP_022650495.1 YlaC family protein -
IBG18_RS17735 3596836..3598296 - 1461 WP_032608667.1 PLP-dependent aminotransferase family protein -
IBG18_RS17740 3598398..3599108 + 711 WP_022650493.1 GNAT family protein -
IBG18_RS17745 3599105..3599245 - 141 WP_032608666.1 type B 50S ribosomal protein L36 -
IBG18_RS17750 3599248..3599508 - 261 WP_015571255.1 type B 50S ribosomal protein L31 -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-69)

Antitoxin

(1-114)


Sequences


Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T199322 WP_015571250.1 NZ_CP072970:3595302-3595520 [Enterobacter sp. BWH 37]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T199322 NZ_CP097320:565066-565638 [Candidatus Mycobacterium methanotrophicum]
ATGAAGCGGCTCGATCTGGTCGTCGGACCCAACGGAGCCGGCAAGTCGACGTTCGTCGAACTCACCTTGGCGCCGCTGCT
GCCCGGCAGTGCCTTCGTCAATGCCGACGAGATCGCCCGACAACGCTGGCCCGATGACCCCGCCTCGCATGCGTATCAGG
CTGCGCGGGTGGCGGCAGAGACGAGGGCCAGGCTCATCGAGGTGGGCGCATCGTTCATCGCCGAGACGGTGTTCTCCCAT
CCGTCAAAGCTCGAACTGATCGATACCGCCCACGCGGGCGACTACACGATCGTCCTGCATGTCATGCTGATCCCCGAGGA
GCTCGCGGTCGAGCGGGTCCGGCACCGCGTCAGCGCCGGCGGACATCATGTGCCCGAGGATAAGATTCGCGAACGCTACC
AACGTCTTTGGGGGCTCGTCGCCGCCGCGACCAGCCGATGCGATTCGACAACCGTGTACGACAACAGCGCGCTGCAAGGC
CCCCGCATCATCGCGCAGATGAACGACGGCTTCCTCGTCGGCTCGTCGGCTTGGCCGGCGTGGACCCCCGACGCCCTCCG
GTCAGGTCGCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT199322 WP_006809850.1 NZ_CP072970:3594900-3595274 [Enterobacter sp. BWH 37]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT199322 NZ_CP097320:564638-565069 [Candidatus Mycobacterium methanotrophicum]
ATGGCGAACACCGCTGATCGAGTGACCCGCGTCGCCGCCGACCTAATGGACAGCGCGGCCGCCGAGGGTGCGCGACAAAG
CCGCTCGGCCAAGCAGCAGCTCGACCACTGGGCGCGGGTGGGACGCGCGGTGTCGAGTCAGCAGACGGCGGCCCGGCGCC
GGGTCGAGGCCGCGCTGACCGGCGATCTGGAGCTGCGCGAGCTGAGCGTCGAAGAGGGCGCGGTGTTCAACGCCGAGATC
GCCGCGGCCGTCGAAGAGAGATTGGCGGGATCGAATTACGGGACGCTGCTGGCCGAGCGCGGCATCACCACCGTGGCCCT
CGACGAGAACGGTGACATCGTCGAGCACCGCCCTGATGGGTCCTCGGTCGTGCTGGCCACGAAACGGCGAGCGCCACGAC
GCAGGAAGGCCCGCGCCGCGCCCACCCGATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A837FFM2


Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References