Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2315884..2316623 Replicon chromosome
Accession NZ_CP072970
Organism Enterobacter sp. BWH 37

Toxin (Protein)


Gene name tacT Uniprot ID A0A837FFP9
Locus tag IBG18_RS11290 Protein ID WP_032609220.1
Coordinates 2316138..2316623 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag IBG18_RS11285 Protein ID WP_003857131.1
Coordinates 2315884..2316150 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IBG18_RS11265 2311360..2312346 + 987 WP_003857123.1 DUF979 domain-containing protein -
IBG18_RS11270 2312356..2313351 + 996 WP_032666403.1 DUF2891 domain-containing protein -
IBG18_RS11275 2313373..2314761 - 1389 WP_032609222.1 MFS transporter -
IBG18_RS11280 2314891..2315820 + 930 WP_032609221.1 LysR family transcriptional regulator -
IBG18_RS11285 2315884..2316150 + 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
IBG18_RS11290 2316138..2316623 + 486 WP_032609220.1 GNAT family N-acetyltransferase Toxin
IBG18_RS11295 2316795..2318198 + 1404 WP_000125668.1 ISNCY family transposase -
IBG18_RS11300 2318231..2318935 - 705 WP_000130816.1 arsenical resistance protein ArsH -
IBG18_RS11305 2319022..2319342 + 321 WP_000941305.1 transcriptional regulator -
IBG18_RS11310 2319388..2320677 + 1290 WP_000922628.1 arsenic transporter -
IBG18_RS11315 2320690..2321115 + 426 WP_000065802.1 glutaredoxin-dependent arsenate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2316795..2318198 1403


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(80-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17554.26 Da        Isoelectric Point: 9.9658

>T199321 WP_032609220.1 NZ_CP072970:2316138-2316623 [Enterobacter sp. BWH 37]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVICKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

>T199321 NZ_CP097320:c554119-553793 [Candidatus Mycobacterium methanotrophicum]
GTGAGACGGGGCGAGCTCTGGACGGCCGCGGGCGGCAAGCACTATGCCGGCAAACCGCGCCCGGTGCTGATTGTCCAAGA
CGATCGGTTTGATGCGACGTCCTCGATTACGGTCTGCCCGTTGACCAGCGATCCCACCGAGATTCCGCTGTTGCGGGTTC
CGCTGGATCCCGATGACAGCAACTGCCTGGATGCACCGAGCAGCATCATGATCGACAAGATCACGACGATGGCGCGGTCC
AAGCTCGGTGCGCGCATCGGCAAAGTTTCGGATGCCGGTATGCTCGCGCTCTCCCGCAGTCTGGTGGTTTTCCTCGGCTT
CGCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT199321 WP_003857131.1 NZ_CP072970:2315884-2316150 [Enterobacter sp. BWH 37]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT199321 NZ_CP097320:c554334-554116 [Candidatus Mycobacterium methanotrophicum]
ATGACTGAACGCAGAGTTCGACACCGGGTCGCCGCCCATCGGGAGCGTTTGCGCCGACAGGGCTTGCGGCCGGTGCAGAT
CTGGGTCCCCGATGTCCGGGCGCCTGGATTCGCGGCTGAGGCTCATCGCCAGTCAGCGTTGGCGGCGGCCAGTCCCCATG
AAGCTGATGATCAGGCTTTTGTCGATGCGATCTCGTCGTTCGGCGACGACGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References