Detailed information of TA system TA199314

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA(toxin)
• Location: 1475969..1477752
• Replicon: chromosome
• Accession: NZ_CP072970
• Organism: Enterobacter sp. BWH 37

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: IBG18_RS07150
• Protein ID: WP_032609694.1
• Coordinates: 1476403..1477752 (-)
• Length: 450 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A837FFV9
• Locus tag: IBG18_RS07145
• Protein ID: WP_003859317.1
• Coordinates: 1475969..1476406 (-)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IBG18_RS07125	1470988..1472010	+	1023	WP_003859324.1	HTH-type transcriptional regulator GalS	-
IBG18_RS07130	1472306..1473304	+	999	WP_003859322.1	galactose/glucose ABC transporter substrate-binding protein MglB	-
IBG18_RS07135	1473384..1474904	+	1521	WP_003859320.1	galactose/methyl galactoside ABC transporter ATP-binding protein MglA	-
IBG18_RS07140	1474920..1475930	+	1011	WP_003859318.1	galactose/methyl galactoside ABC transporter permease MglC	-
IBG18_RS07145	1475969..1476406	-	438	WP_003859317.1	helix-turn-helix transcriptional regulator	Antitoxin
IBG18_RS07150	1476403..1477752	-	1350	WP_032609694.1	HipA domain-containing protein	Toxin
IBG18_RS07155	1477887..1478597	-	711	WP_003859314.1	outer membrane permeability protein SanA	-
IBG18_RS07160	1478725..1479609	-	885	WP_032609693.1	cytidine deaminase	-
IBG18_RS07165	1479738..1480433	-	696	WP_003859310.1	CidB/LrgB family autolysis modulator	-
IBG18_RS07170	1480430..1480825	-	396	WP_003859308.1	CidA/LrgA family protein	-
IBG18_RS07175	1480994..1481929	+	936	WP_003859306.1	tRNA dihydrouridine(16) synthase DusC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-406)

Antitoxin

• Cro/C1-type helix-turn-helix domain (75-128)

Sequences

Toxin

Protein

• Length: 450 a.a.
• Molecular weight: 51149.84 Da
• Isoelectric Point: 4.6562

>T199314 WP_032609694.1 NZ_CP072970:c1477752-1476403 [Enterobacter sp. BWH 37]
METLTVQAYLNETWTDIALIKYPGSEKNDWNITQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESVPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHEINAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL

Nucleotide

• Length: 1350 bp

>T199314 NZ_CP097295:c60719-60417 [Vibrio sp. J383]
ATGACGCACTATAAGCTCTCTTCTTCAGCGCAATCTGATCTGATTGAGATTCGTCGCTATACATTAGAGCGATGGGGGCA
AGCACAATGGACTACTTACTTTTCAGAACTAAAGCAATCAATGGAATTACTGGCGAACAACAAGTTGCTCGGCATAGAGG
TTTCTGAGGTGGGCCAAAACTACTTCCGTTTTCCTTTAAAGCGCCATGTGATTTATTACATCCAGAAACAAGATCACATA
ATTATTACAGCCGTTCTTGGTAAGCACATGTCTCCGGCTAAGCACTTTTCACAGCTATCTTAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 16185.64 Da
• Isoelectric Point: 10.5154

>AT199314 WP_003859317.1 NZ_CP072970:c1476406-1475969 [Enterobacter sp. BWH 37]
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEEPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS

Nucleotide

• Length: 438 bp

>AT199314 NZ_CP097295:c60979-60719 [Vibrio sp. J383]
ATGCAATCACTTACTGCGAATACAGCTAAAACCAAATTTGGCGACTTACTGATGAAAGTTCAACGTGAACCTATACAAAT
TAATAAGAATGGTTCACCCGTTGCGGTGATGATGTCTTTTGAAGAATATGAACAACTTGAAGCACTGAAATTGATGGTGG
TGAAATCACGCTTCGAACAAGCAGAAGCCGATGCTCTATCAGATAAACTAGTCGACGGTGACGATTTCATGAATGCACTT
AACCAAGGAAAGTTTGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A837FFV9