Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 834363..835020 Replicon chromosome
Accession NZ_CP072970
Organism Enterobacter sp. BWH 37

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag IBG18_RS04105 Protein ID WP_022649305.1
Coordinates 834610..835020 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag IBG18_RS04100 Protein ID WP_003863437.1
Coordinates 834363..834629 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IBG18_RS04080 829795..831228 - 1434 WP_003863430.1 6-phospho-beta-glucosidase BglA -
IBG18_RS04085 831345..832076 - 732 WP_023314798.1 MurR/RpiR family transcriptional regulator -
IBG18_RS04090 832343..833002 + 660 WP_003863433.1 hemolysin III family protein -
IBG18_RS04095 833088..834068 - 981 WP_022649306.1 tRNA-modifying protein YgfZ -
IBG18_RS04100 834363..834629 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
IBG18_RS04105 834610..835020 + 411 WP_022649305.1 protein YgfX Toxin
IBG18_RS04110 835022..835543 - 522 WP_003863440.1 flavodoxin FldB -
IBG18_RS04115 835645..836541 + 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
IBG18_RS04120 836570..837283 + 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IBG18_RS04125 837289..839022 + 1734 WP_032610082.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T199313 WP_022649305.1 NZ_CP072970:834610-835020 [Enterobacter sp. BWH 37]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T199313 NZ_CP097294:1807070-1807360 [Vibrio sp. J383]
ATGACCTATAAACTCGACTTTAAAAAGAGTGCACTCAAAGAGTGGAAAAAGCTTGGCTCAACGCTTCAACAACAATTTAA
GAAAAAGCTAATCGAGCGTTTAGATAACCCGCATGTTCCGGCTTCAAAACTCTCTGGAGCTGACAACATGTATAAGATTA
AGCTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCTTAGCAGTCGGAAAA
CGCGAACGTAGCGATGTTTACCGTAAAGCTATGAAAAGGTTAGATGATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT199313 WP_003863437.1 NZ_CP072970:834363-834629 [Enterobacter sp. BWH 37]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT199313 NZ_CP097294:1806832-1807080 [Vibrio sp. J383]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGTGAACCTGTTGCTGTACTGAACCGAAATGAGCCAGCATTTTATTGCGTACCAGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTAACTATTGCGAAAGAGCGTGAATCTGAAGAGAGTATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References