Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 82093..82736 Replicon plasmid unnamed2
Accession NZ_CP072963
Organism Enterobacter sp. MGH 14

Toxin (Protein)


Gene name vagD Uniprot ID A0A6C0NE46
Locus tag IBG17_RS25885 Protein ID WP_008322233.1
Coordinates 82093..82509 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag IBG17_RS25890 Protein ID WP_001261276.1
Coordinates 82506..82736 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IBG17_RS25865 78163..79182 + 1020 WP_004113181.1 ribose ABC transporter permease -
IBG17_RS25870 79260..80630 + 1371 WP_008322237.1 hypothetical protein -
IBG17_RS25875 80627..81547 + 921 WP_008322235.1 carbohydrate kinase -
IBG17_RS25885 82093..82509 - 417 WP_008322233.1 type II toxin-antitoxin system VapC family toxin Toxin
IBG17_RS25890 82506..82736 - 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
IBG17_RS25895 82989..84011 - 1023 WP_008322227.1 helicase UvrD -
IBG17_RS25900 84097..84801 + 705 WP_001067848.1 IS6-like element IS26 family transposase -
IBG17_RS25905 85204..85560 + 357 WP_000215515.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(D) / blaTEM-1A / aph(3')-Ia - 1..199350 199350


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15054.58 Da        Isoelectric Point: 9.2957

>T199311 WP_008322233.1 NZ_CP072963:c82509-82093 [Enterobacter sp. MGH 14]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAASAVLVTNNVREFARVPGLMLEDWVK

Download         Length: 417 bp

>T199311 NZ_CP097294:171282-171539 [Vibrio sp. J383]
ATGAATATTGTTTCTTTTACTGAGGCAAGAAATAGCCTTAAGTCTGTGCTCGATAGAGTGGTAGACGATTCTGATGTTAC
GGTAATAACCAGACGAGATTCAGAAGATGCCGTGGTAATGTCTCTTGATCATTTTAATTCAATGCAAGAAACCTTGTACC
TAATGAGCTCGCCTAAAAACGCTGAAAGATTGGCTGAATCCATTGCTCAACTCGAAGCCGGAAATACAACCGTTCGAGAA
TTGAATAATGACGAATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT199311 WP_001261276.1 NZ_CP072963:c82736-82506 [Enterobacter sp. MGH 14]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT199311 NZ_CP097294:171529-171795 [Vibrio sp. J383]
ATGACGAATGATCGAAAGATTGTATTTACAGATAATGCTTGGGAAGATTACCTATACTGGCAAACCCAAGACAAGAAAAC
GCTCAAGAAACTAAATAAGTTGATTGAAGCTGCCAAAAGAACGCCCTTTGAAGGGATTGGAAAGCCGGAGCCACTAGTCG
GCAACCTGTCTGGATTTTGGTCAAGACGAATCGATGACAAGAATCGATTAGTGTATAAAGCAGATGACGATAACTTTTAC
ATAATTGCTTGTCGTCACCACTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C0NE46

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References