Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 277108..277634 Replicon plasmid unnamed1
Accession NZ_CP072962
Organism Enterobacter sp. MGH 14

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag IBG17_RS24700 Protein ID WP_000323025.1
Coordinates 277108..277395 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag IBG17_RS24705 Protein ID WP_000534858.1
Coordinates 277395..277634 (-) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IBG17_RS24665 272678..272854 - 177 WP_001371930.1 hypothetical protein -
IBG17_RS24670 273365..274309 + 945 WP_000778029.1 DUF5417 domain-containing protein -
IBG17_RS24675 274405..275007 + 603 WP_012695474.1 hypothetical protein -
IBG17_RS24680 275067..275417 + 351 WP_000743059.1 hypothetical protein -
IBG17_RS24685 275464..275667 + 204 WP_001015183.1 hypothetical protein -
IBG17_RS24690 275949..276269 + 321 WP_000332796.1 hypothetical protein -
IBG17_RS24695 276882..277007 - 126 WP_229020258.1 DUF5431 family protein -
IBG17_RS24700 277108..277395 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
IBG17_RS24705 277395..277634 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
IBG17_RS26865 277659..277763 + 105 Protein_287 hypothetical protein -
IBG17_RS24710 277897..278820 - 924 WP_000167917.1 cation diffusion facilitator family transporter -
IBG17_RS24715 279020..279592 - 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
IBG17_RS24720 280068..281306 - 1239 WP_000219087.1 IS110-like element ISEsa2 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaSHV-30 / blaKPC-3 / aac(6')-Ib / ant(3'')-Ia / blaOXA-9 / blaTEM-1A / blaTEM-1B / aadA2 / qacE / sul1 / qnrB2 / dfrA19 / aph(3'')-Ib / aph(6)-Id / mcr-9 / aph(3')-Ia - 1..423968 423968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T199308 WP_000323025.1 NZ_CP072962:c277395-277108 [Enterobacter sp. MGH 14]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T199308 NZ_CP097291:3826476-3826730 [Providencia sp. PROV188]
ATGAAAACCATTTCCTTTAGTGATGCTAGAAGCAATTTGAAAGCAGTGCTTGATAGAGTTGTTGATGATATGGATACGAC
GATTATAACCCGCCGTGATTCTGAAGCGGCTGTAGTTATGTCCTTGGAATACTACAATAGTTTAATGGAAACCATCTACC
TATTGCGCTCTCCTGCAAATGCAGAGCATCTCAACAAATCCATCGAGCAATTTAAAGCGGGTAAGATTTCAGAGAGAAAG
CTAATCAATGAGTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT199308 WP_000534858.1 NZ_CP072962:c277634-277395 [Enterobacter sp. MGH 14]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT199308 NZ_CP097291:3826723-3826983 [Providencia sp. PROV188]
ATGAGTAGACTTCTAACATGGACGGATCAAGCTTGGGAAGATTATCTATACTGGCAAAGCCAAGATAAAAAGACATTAAA
GCGGATCAATAAACTCATTGAAGACACAAAAAGAACGCCATTCAGCGGTATAGGTAAACCAGAGCCACTAAAAGAAAACT
TAGCTGGCTTCTGGTCTCGTAGAATAGATGAAACTAATAGGCTAGTTTATGCAATCGAAAATACCGCACTAATCATCATT
GCCTGTCGCTATCATTACTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References